公开(公告)号：US20080312221A1

公开(公告)日：2008-12-18

申请号：US12175361

申请日：2008-07-17

申请人： Yasunari Fujiwara ,  Terufumi Senga ,  Tsuyoshi Nishitoba ,  Tatsushi Osawa ,  Atsushi Miwa ,  Kazuhide Nakamura

发明人： Yasunari Fujiwara ,  Terufumi Senga ,  Tsuyoshi Nishitoba ,  Tatsushi Osawa ,  Atsushi Miwa ,  Kazuhide Nakamura

IPC分类号： A61K31/47 ,  C07D215/233 ,  C07D413/12 ,  A61K31/541 ,  A61P35/00 ,  A61K31/5377 ,  C07D417/12

CPC分类号： C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  C07D215/40 ,  C07D239/88 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

摘要： An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X=CH or N; Z=O or S; L=O or S; M=CR10R11, wherein R10 and R11=H, alkyl, or alkoxy, NR12 wherein R12=H or alkyl; R1, R2, and R3=H or optionally substituted alkoxy; R4=H; R5-8=H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by —R14, -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19=H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.

摘要翻译： 本发明的目的是提供具有有效抗肿瘤活性的化合物。 本发明的化合物由式（I）表示或其药学上可接受的盐或溶剂化物：其中X = CH或N; Z = O或S; L = O或S; M = CR10R11，其中R10和R11 = H，烷基或烷氧基，NR12，其中R12 = H或烷基; R1，R2和R3 = H或任选取代的烷氧基; R4 = H; R5-8 = H，卤素，烷氧基等; 并且R 9 =任选被-R 14，-T-R 15或-NR 16 R 17取代的烷基，其中T = O，S或NH; R14 =任选取代的碳环或杂环; 和R 15-17 =烷基或任选取代的碳环或杂环，或-NR 18 R 19，其中R 18和R 19 = H，任选取代的烷基，或任选取代的碳环或杂环，或任选取代的碳环或杂环。

公开(公告)号：US07425564B2

公开(公告)日：2008-09-16

申请号：US10480632

申请日：2002-06-21

申请人： Yasunari Fujiwara ,  Terufumi Senga ,  Tsuyoshi Nishitoba ,  Tatsushi Osawa ,  Atsushi Miwa ,  Kazuhide Nakamura

发明人： Yasunari Fujiwara ,  Terufumi Senga ,  Tsuyoshi Nishitoba ,  Tatsushi Osawa ,  Atsushi Miwa ,  Kazuhide Nakamura

IPC分类号： A61K31/47

CPC分类号： C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  C07D215/40 ,  C07D239/88 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

摘要： An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X=CH or N; Z=O or S; L=O or S; M=CR10R11, wherein R10 and R11=H, alkyl, or alkoxy, NR12 wherein R12=H or alkyl; R1, R2, and R3=H or optionally substituted alkoxy; R4=H; R5-8=H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by —R14, -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19=H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.

摘要翻译： 本发明的目的是提供具有有效抗肿瘤活性的化合物。 本发明的化合物由式（I）表示或其药学上可接受的盐或溶剂化物：其中X = CH或N; Z = O或S; L = O或S; 其中R 10和R 11 = H，烷基或烷氧基，NR（R 11） 其中R 12 = H或烷基; R 1，R 2和R 3 = H或任选取代的烷氧基; R 4 = H; R 5〜8 = H，卤素，烷氧基等; 和R 9 =任选被-R 14，-TR 15或-NR 16 R 15取代的烷基， 其中T = O，S或NH; R 14是任选取代的碳环或杂环; 和R 15-17 =烷基或任选取代的碳环或杂环，或-NR 18 R 19其中R 18， R 00和R 19 = H，任选取代的烷基，或任选取代的碳环或杂环，或任选取代的碳环或杂环。

公开(公告)号：US08324245B2

公开(公告)日：2012-12-04

申请号：US12987610

申请日：2011-01-10

申请人： Yasunari Fujiwara ,  Terufumi Senga ,  Tsuyoshi Nishitoba ,  Tatsushi Osawa ,  Atsushi Miwa ,  Kazuhide Nakamura

发明人： Yasunari Fujiwara ,  Terufumi Senga ,  Tsuyoshi Nishitoba ,  Tatsushi Osawa ,  Atsushi Miwa ,  Kazuhide Nakamura

IPC分类号： A61K31/04 ,  C07D215/38

CPC分类号： C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  C07D215/40 ,  C07D239/88 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

摘要： An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X═CH or N; Z═O or S; L=O or S; M=CR10R11, wherein R10 and R11═H, alkyl, or alkoxy, NR12 wherein R12═H or alkyl; R1, R2, and R3═H or optionally substituted alkoxy; R4═H; R5-8═H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by —R14, -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19═H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.

摘要翻译： 本发明的目的是提供具有有效抗肿瘤活性的化合物。 本发明的化合物由式（I）表示或其药学上可接受的盐或溶剂合物：其中X = CH或N; Z = O或S; L = O或S; M = CR10R11，其中R10和R11 = H，烷基或烷氧基，NR12，其中R12 = H或烷基; R1，R2和R3 = H或任选取代的烷氧基; R4 = H; R5-8 = H，卤素，烷氧基等; 并且R 9 =任选被-R 14，-T-R 15或-NR 16 R 17取代的烷基，其中T = O，S或NH; R14 =任选取代的碳环或杂环; 和R 15-17 =烷基或任选取代的碳环或杂环，或-NR 18 R 19，其中R 18和R 19 = H，任选取代的烷基，或任选取代的碳环或杂环，或任选取代的碳环或杂环。

公开(公告)号：US07495104B2

公开(公告)日：2009-02-24

申请号：US10491898

申请日：2002-10-17

申请人： Atsushi Miwa ,  Tetsuya Yoshino ,  Tatsushi Osawa ,  Teruyuki Sakai ,  Toshiyuki Shimizu ,  Yasunari Fujiwara

发明人： Atsushi Miwa ,  Tetsuya Yoshino ,  Tatsushi Osawa ,  Teruyuki Sakai ,  Toshiyuki Shimizu ,  Yasunari Fujiwara

IPC分类号： C07D215/38 ,  C07D239/72 ,  A61K31/47

CPC分类号： C07D215/233 ,  C07D239/88 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02

摘要： An objective of the present invention is to provide novel compounds which have inhibitory activity against autophosphorylation of an FGF receptor family and, when orally or intraveneously administered, can suppress the growth of cancer cells. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents O or S; Q represents NR10, CR11R2, carbonyl, O, S(═O)m, wherein m is 0 to 2, or urea; R1 to R3 each independently represent H, OH, halogen, nitro, amino, alkyl, alkoxy or the like in which the alkyl and alkoxy groups are optionally substituted; R4 represents H; R5 to R8 each independently represent H, halogen, alkyl, or alkoxy; and R9 represents an optionally substituted carbocyclic or heterocyclic group.

摘要翻译： 本发明的目的是提供对FGF受体家族的自磷酸化具有抑制活性的新型化合物，并且当口服或经受干预时可抑制癌细胞的生长。 本发明的化合物由式（I）表示或其药学上可接受的盐或溶剂合物：其中X表示CH或N; Z表示O或S; Q表示NR10，CR11R2，羰基，O，S（-O）m，其中m为0至2，或脲; R 1至R 3各自独立地表示其中烷基和烷氧基任选被取代的H，OH，卤素，硝基，氨基，烷基，烷氧基等; R4表示H; R5至R8各自独立地表示H，卤素，烷基或烷氧基; 并且R 9表示任选取代的碳环或杂环基。

公开(公告)号：US20050049264A1

公开(公告)日：2005-03-03

申请号：US10491898

申请日：2002-10-17

申请人： Atsushi Miwa ,  Tetsuya Yoshino ,  Tatsushi Osawa ,  Teruyuki Sakai ,  Toshiyuki Shimizu ,  Yasunari Fujiwara

发明人： Atsushi Miwa ,  Tetsuya Yoshino ,  Tatsushi Osawa ,  Teruyuki Sakai ,  Toshiyuki Shimizu ,  Yasunari Fujiwara

IPC分类号： A61P1/00 ,  A61P1/18 ,  A61P11/00 ,  A61P13/12 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C07D215/22 ,  C07D215/233 ,  C07D239/88 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  A61K31/517 ,  A61K31/47

CPC分类号： C07D215/233 ,  C07D239/88 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02

摘要： An objective of the present invention is to provide novel compounds which have inhibitory activity against autophosphorylation of an FGF receptor family and, when orally or intraveneously administered, can suppress the growth of cancer cells. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents O or S; Q represents NR10, CR11R2, carbonyl, O, S(═O)m, wherein m is 0 to 2, or urea; R1 to R3 each independently represent H, OH, halogen, nitro, amino, alkyl, alkoxy or the like in which the alkyl and alkoxy groups are optionally substituted; R4 represents H; R5 to R8 each independently represent H, halogen, alkyl, or alkoxy; and R9 represents an optionally substituted carbocyclic or heterocyclic group.

摘要翻译： 本发明的目的是提供对FGF受体家族的自磷酸化具有抑制活性的新型化合物，并且当口服或经受干预时可抑制癌细胞的生长。 本发明的化合物由式（I）表示或其药学上可接受的盐或溶剂合物：其中X表示CH或N; Z表示O或S; Q表示NR 10，CR 11 R 2，羰基，O，S（= O）m，其中m为0至2，或脲; R 1至R 3各自独立地表示其中烷基和烷氧基任选被取代的H，OH，卤素，硝基，氨基，烷基，烷氧基等; R 4表示H; R 5至R 8各自独立地表示H，卤素，烷基或烷氧基; 并且R 9表示任选取代的碳环或杂环基。

公开(公告)号：US20060211717A1

公开(公告)日：2006-09-21

申请号：US11432407

申请日：2006-05-12

申请人： Teruyuki Sakai ,  Terufumi Senga ,  Takayuki Furuta ,  Atsushi Miwa

发明人： Teruyuki Sakai ,  Terufumi Senga ,  Takayuki Furuta ,  Atsushi Miwa

IPC分类号： A61K31/517 ,  C07D403/02

CPC分类号： C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/505 ,  A61K31/517 ,  A61K31/5377 ,  C07D231/12 ,  C07D233/56 ,  C07D233/88 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： There are provided compounds which can be used in the treatment of diseases mediated by the autophosphorylation of a PDGF receptor, specifically, compounds which can inhibit neointima formation hypertrophy. The compounds are those represented by formula (I) or pharmacologically acceptable salts or solvates thereof: wherein R1 and R2 represent hydrogen, alkyl or the like; R3, R4, R5, and R6 represent hydrogen, halogen, alkyl, alkoxy or the like; R11 and R12 represent hydrogen, alkyl, alkylcarbonyl or the like; and A represents any one of formulae (i) to (x), provided that compounds wherein R3, R4, R5 and R6 represent hydrogen and A represents group (v) wherein u is 0 (zero) and R19 represents phenyl optionally substituted by halogen, alkyl, or alkoxy are excluded.

摘要翻译： 提供的化合物可用于治疗由PDGF受体的自磷酸化介导的疾病，特别是可抑制新内膜形成肥大的化合物。 化合物是由式（I）表示的化合物或其药学上可接受的盐或溶剂化物：其中R 1和R 2代表氢，烷基等; R 3，R 4，R 5和R 6代表氢，卤素，烷基，烷氧基或 喜欢; R 11和R 12代表氢，烷基，烷基羰基等; 并且A表示式（i）至（x）中的任何一个，条件是其中R 3，R 4，R 5和R 5的化合物 代表氢，A代表其中u为0（零）且R 19表示任选被卤素，烷基或烷氧基取代的苯基的基团（ⅴ）。

公开(公告)号：US20090270391A1

公开(公告)日：2009-10-29

申请号：US11910078

申请日：2006-03-28

申请人： Kazuo Kubo ,  Takayuki Furuta ,  Tatsushi Osawa ,  Atsushi Miwa

发明人： Kazuo Kubo ,  Takayuki Furuta ,  Tatsushi Osawa ,  Atsushi Miwa

IPC分类号： A61K31/5377 ,  C07D495/04 ,  A61K31/4365 ,  A61K31/4709 ,  C07D401/12 ,  C07D413/12 ,  A61P35/00

CPC分类号： C07D495/04 ,  C07D401/12 ,  C07D471/04

摘要： An objective of the present invention is to provide compounds having antitumor activity. According to the present invention, there is provided compounds represented by formula (I) and pharmaceutically acceptable salts thereof, and solvates thereof: wherein R1 represents H or a substitutable unsaturated five- or six-membered heterocyclic ring; R2 represents H; X represents CH or N; Z represents O or S; E is absent or represents halogen, alkyl, or alkoxy; J represents S or O; and T represents phenyl, an unsaturated five- or six-membered heterocyclic ring, an unsaturated nine- or ten-membered bicyclic carbocyclic ring or heterocyclic ring.

摘要翻译： 本发明的目的是提供具有抗肿瘤活性的化合物。 根据本发明，提供式（I）表示的化合物及其药学上可接受的盐及其溶剂合物：其中R1表示H或可取代的不饱和五元或六元杂环; R2表示H; X表示CH或N; Z表示O或S; E不存在或表示卤素，烷基或烷氧基; J表示S或O; 和T表示苯基，不饱和五元或六元杂环，不饱和九元或十元双环碳环或杂环。

公开(公告)号：US08434757B2

公开(公告)日：2013-05-07

申请号：US13406874

申请日：2012-02-28

申请人： Atsushi Miwa

发明人： Atsushi Miwa

IPC分类号： B65H3/34 ,  B65H3/52

CPC分类号： B65H1/04 ,  B65H3/0669 ,  B65H3/0684 ,  B65H3/34 ,  B65H3/56 ,  B65H2301/4222 ,  B65H2404/725 ,  B65H2511/152 ,  B65H2511/20 ,  B65H2220/01 ,  B65H2220/02 ,  B65H2220/08

摘要： A sheet feeder includes a loading surface, a supply roller configured to feed recording sheets loaded on the loading surface, an overload prevention member disposed upstream from the supply roller in a sheet feed direction, and a movable member disposed downstream from the overload prevention member in the sheet feed direction. The overload prevention member includes a restriction surface configured to be moved between a first position and a second position. The movable member is configured to be moved from a third position to a fourth position by being pushed by leading ends of the recording sheets. The movable member and the overload prevention member are configured to interlock each other such that, when the movable member is in the third position, the restriction surface is in the first position, and when the movable member is in the fourth position, the restriction surface is in the second position.

摘要翻译： 送纸器包括装载表面，供给辊，其构造成供给装载在装载表面上的记录纸张;防过载部件，其沿供纸方向设置在供给辊上游;以及可移动部件，设置在过载防止部件的下游 送纸方向。 过载防止构件包括构造成在第一位置和第二位置之间移动的限制表面。 可移动部件被构造成通过被记录片材的前端推动而从第三位置移动到第四位置。 可动构件和过载防止构件被构造成彼此互锁，使得当可动构件处于第三位置时，限制表面处于第一位置，并且当可动构件处于第四位置时，限制表面 处于第二位。

公开(公告)号：US20140111569A1

公开(公告)日：2014-04-24

申请号：US14140068

申请日：2013-12-24

申请人： Atsushi Miwa

发明人： Atsushi Miwa

IPC分类号： B41J2/175

CPC分类号： B41J2/17596 ,  B41J2/175 ,  B41J2/17513 ,  B41J29/02 ,  B41J29/38

摘要： An image forming apparatus includes an apparatus body, a recording head, head tanks, main tanks, liquid feed pumps, a first driving source, a drive control unit, and a drive switching assembly. The drive switching assembly includes a second driving source, a cam, a slider member, a switching gear, switching position detected portions, and a detector. The detected portions are disposed at the cam so as to correspond to switching positions of the liquid feed pumps. One of the detected portions has a greater width in a rotation direction of the cam than any other detected portion. When a time from when the detector detects one of the detected portions to when the detector detects another one of the detected portions is shorter than a threshold value, the drive control unit determines, as a home position, a position of the cam on detection of the another one with the detector.

摘要翻译： 图像形成装置包括装置主体，记录头，头箱，主箱，给液泵，第一驱动源，驱动控制单元和驱动切换组件。 驱动切换组件包括第二驱动源，凸轮，滑动构件，切换齿轮，切换位置检测部分和检测器。 所检测的部分设置在凸轮处，以对应于液体供给泵的切换位置。 检测到的部分之一在凸轮的旋转方向上比任何其它检测部分具有更大的宽度。 当检测器检测到检测到的部分之一到检测器检测到另一个检测部分的时间比阈值短时，驱动控制单元将起始位置确定为检测到的凸轮的位置 另一个与检测器。

公开(公告)号：US08070152B2

公开(公告)日：2011-12-06

申请号：US12492761

申请日：2009-06-26

申请人： Atsushi Miwa ,  Makoto Hattori

发明人： Atsushi Miwa ,  Makoto Hattori

IPC分类号： B65H5/00

CPC分类号： B65H3/0684 ,  B65H7/18 ,  B65H2511/514 ,  B65H2513/511 ,  B65H2513/512 ,  B65H2553/412 ,  B65H2701/1311 ,  B65H2701/1313 ,  B65H2801/06 ,  B65H2220/01 ,  B65H2220/02 ,  B65H2220/03

摘要： A sheet supplying unit that supplies sheets includes a sheet accommodation tray that accommodates the sheets in a stacked state, the sheets including a first sheet which is an uppermost sheet in the stack of the sheets and a second sheet which is immediately below the first sheet; a pick-up roller that conveys the sheets in a sheet conveying direction; a detection sensor that detects passage of the sheets and is disposed downstream of the pick-up roller in the sheet conveying direction; and a control unit that controls operations of the pick-up roller in accordance with outputs from the detection sensor. The control unit includes a driving section that drives the pick-up roller to start conveying the second sheet when the detection sensor detects a trailing edge of the first sheet, if the second sheet is to be fed; a suspending section that temporarily stops driving the pick-up roller for a time period α-β when the detection sensor detects a leading edge of the second sheet, α being a predetermined time period, and β being a time period from a timing when the detection sensor detects the trailing edge of the first sheet to a timing when the detection sensor detects the leading edge of the second sheet; and a resuming section that resumes driving the pick-up roller to convey the second sheet after suspending for the time period α-β.

摘要翻译： 供给片材的片材供给单元包括容纳片材的层叠状态的片材容纳盘，所述片材包括作为片材堆叠中的最上层片材的第一片材​​和位于第一片材的正下方的第二片材; 拾纸辊，其在纸张传送方向上传送纸张; 检测传感器，其检测片材的通过并且设置在片材输送方向上的拾取辊的下游; 以及控制单元，其根据来自检测传感器的输出来控制拾取辊的操作。 所述控制单元包括驱动部，当所述检测传感器检测到所述第一片的后缘时，驱动所述拾取辊开始输送所述第二片，如果所述第二片要被馈送; 一个暂时停止驱动拾取辊一段时间α＆bgr的悬挂部分; 当检测传感器检测到第二片的前缘时，α为预定的时间段，并且＆bgr; 是从检测传感器检测到第一片的后缘到检测传感器检测到第二片的前缘的定时的时间段; 以及恢复部分，其恢复驱动所述拾取辊以在暂停所述时间段α＆bgr之后传送所述第二片材。