发明申请
- 专利标题： PYRIMIDINE COMPOUND AND MEDICAL USE THEREOF
- 专利标题（中）： 吡嗪类化合物及其医疗用途
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申请号： US12053133申请日： 2008-03-21
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公开(公告)号： US20080312228A1公开(公告)日： 2008-12-18
- 发明人: Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
- 申请人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
- 申请人地址： JP Tokyo
- 专利权人： Japan Tobacco Inc.
- 当前专利权人： Japan Tobacco Inc.
- 当前专利权人地址： JP Tokyo
- 优先权： JP2004-174770 20040611; JP2004-327111 20041110
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/519 ; A61K31/5377 ; A61K31/496 ; A61P35/00
摘要：
The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
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