摘要:
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-N-sulfonylaminocyclopropane compound of formula (1) wherein R1 is —W-A1-W1-A2, W is —(CH2)m—X—(CH2)n—, wherein W1 is —(CH2)m1—X1—(CH2)n1—, m, m1, n and n1 are the same or different and each is 0 to 6, X and X1 are the same or different and each is a single bond, etc., A1 is an optionally substituted C3-14 hydrocarbon ring group, etc. and A2 is a substituted C3-14 hydrocarbon ring group etc.; R2 is —(CH2)r—CO—R8, etc., wherein r is 0 to 6 and R8 is a C1-6 alkoxy group, etc.; R3 and R4 are the same or different and each is a hydrogen atom, a C1-6 alkyl group, etc.; and R5 is —CO2R21, etc.; R30 and R31 are the same or different and each is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要:
The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
摘要:
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-N-sulfonylaminocyclopropane compound of formula (1): wherein R1 is —W-A1—W1-A2, W is —(CH2)m—X—(CH2)n—, wherein W1 is —(CH2)m1—X1—(CH2)n1—, m, m1, n and n1 are the same or different and each is 0 to 6, X and X1 are the same or different and each is a single bond, etc., A1 is an optionally substituted C3-14 hydrocarbon ring group, etc. and A2 is a substituted C3-14 hydrocarbon ring group etc.; R2 is —(CH2)r—CO—R8, etc., wherein r is 0 to 6 and R8 is a C1-6 alkoxy group, etc.; R3 and R4 are the same or different and each is a hydrogen atom, a C1-6 alkyl group, etc.; and R5 is —CO2R21 etc.; R30 and R31 are the same or different and each is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要:
The object of the present invention is to form the fine structure on a cathode surface homogeneously and reproducibly to realize the increased emission current value and stability with a simple process in the electron emission element forming process. An electron emission part of an electron emission element that is a crystalline thin film of electron emissive material formed in self-aligning fashion by means of a laser ablation process, in which a laser beam is irradiated onto a target material and the material ejected and emitted from the target material is deposited to form a thin film on a substrate facing to the target, is used as the thin film electron source. The above-mentioned structure is effective to realize the low electron emission threshold value and the increased emission current value and stability, and realize the reduced cost with the structure that is simpler than the conventional structure.
摘要:
A femoral knee implant includes a fourth compartment of articulation. The superior posterior articulating surface is achieved by first increasing the thickness of the superior posterior condylar portion of the femoral component to widen the superior posterior edge of the posterior condyle. Second, the newly created surface at the superior posterior condyle is smoothly rounded to provide an articular surface with no sharp changes in the surface contours. In one embodiment, the fourth articular compartment of this invention is provided in a one piece femoral design. In another embodiment, it is provided as a modular addition to an existing prior art femoral component. In another embodiment, the fourth compartment is combined with a posterior stabilized (PS) TKR design that includes a tibial post and cooperating femoral cam characterized by low engagement of the cam on the spine.
摘要:
An organic light emitter includes an anode and a cathode. A first layer of organic material includes a light emitting layer. The first layer extends between the anode and the cathode. A second layer has a refractive index higher than a refractive index of the light emitting layer. The second layer is optically coupled to the light emitting layer, causing an optical waveguide which propagates light generated by the light emitting layer along a direction parallel to a surface of a substrate. At least part of the optical waveguide has an effective refractive index which spatially and periodically varies in a direction parallel to the surface of the substrate.
摘要:
The invention is a field-emission element having a cathode with a sharp apex and a gate with an aperture diameter less than 1 .mu.m that is fabricated by covering a silicon substrate with a silicon oxide layer, forming an etching mask of 1.0 .mu.m diameter from a silicon oxide layer by photolithography, wet-etching the etching mask to form a minute etching mask of less diameter, dry etching the substrate to form a cylindrical solid structure, followed by anisotropic etching to form a couple of minute conical-shaped structures facing each other and connected by their respective tops, vacuum evaporating around the minute structures an insulating layer and thereon a conducting layer for use as a gate electrode, and etching the minute structure to lift off the upper part of the minute conical shaped structures.
摘要:
A phase lock type semiconductor laser comprising: an array type semiconductor laser main body which includes a plurality of line-shaped active layers having wave guides disposed in parallel with each other, these active layers having waveguide modes optically coupled with each other, and a reflection-type light diffraction element executing a light return or feedback in such a manner that only a specific wavelength beam among emitted beams of coupling modes which are emitted from one end surface of the semiconductor laser main body in terms of a line-shaped light source can be directly focused on the same one end surface of the semiconductor laser main body in a line-shaped.
摘要:
An optical pick-up for an optical disk has a semiconductor laser having an optical axis for generating a laser beam. An objective lens focuses the laser beam onto an optical disk disposed in the path of the optical axis of the semiconductor laser. A wavelength between the semiconductor laser and the objective lens has a plurality of input grating couplers for coupling the laser beam reflected from the optical disk into the waveguide for propagating beams in a plurality of directions. A plurality of output grating couplers radiate the propagated beams from the waveguide. A plurality of photodetectors detect the radiated beams from the output grating couplers.
摘要:
The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.