公开(公告)号：US07378423B2

公开(公告)日：2008-05-27

申请号：US11150792

申请日：2005-06-10

申请人： Hisashi Kawasaki ,  Hiroyuki Abe ,  Kazuhide Hayakawa ,  Tetsuya Iida ,  Shinichi Kikuchi ,  Takayuki Yamaguchi ,  Toyomichi Nanayama ,  Hironori Kurachi ,  Masahiro Tamaru ,  Yoshikazu Hori ,  Mitsuru Takahashi ,  Takayuki Yoshida ,  Toshiyuki Sakai

发明人： Hisashi Kawasaki ,  Hiroyuki Abe ,  Kazuhide Hayakawa ,  Tetsuya Iida ,  Shinichi Kikuchi ,  Takayuki Yamaguchi ,  Toyomichi Nanayama ,  Hironori Kurachi ,  Masahiro Tamaru ,  Yoshikazu Hori ,  Mitsuru Takahashi ,  Takayuki Yoshida ,  Toshiyuki Sakai

IPC分类号： A61K31/519 ,  C07D487/04 ,  C07D413/10 ,  C07D413/12 ,  A61P35/00 ,  A61P31/5355

CPC分类号： C07D471/04 ,  A61K31/519 ,  C07C275/30 ,  C07C275/50 ,  C07C2601/16 ,  C07D239/545 ,  C07D239/553 ,  C07D239/62 ,  C07D471/16 ,  C07D487/04 ,  C07F9/53

摘要： The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.

摘要翻译： 本发明涉及由下式[I]表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如说明书中所定义，以及治疗或预防性治疗不期望的细胞增殖的方法，包括施用这种化合物。 本发明的化合物在抑制不期望的细胞增殖，特别是抗肿瘤活性方面具有优异的活性，可用作预防或治疗癌症，风湿病等的抗肿瘤剂。 此外，当与其它抗肿瘤剂如烷化剂或代谢拮抗剂组合使用时，本发明的化合物可以是更有效的抗肿瘤剂。

公开(公告)号：US08835443B2

公开(公告)日：2014-09-16

申请号：US12626443

申请日：2009-11-25

申请人： Hisashi Kawasaki ,  Hiroyuki Abe ,  Kazuhide Hayakawa ,  Tetsuya Iida ,  Shinichi Kikuchi ,  Takayuki Yamaguchi ,  Toyomichi Nanayama ,  Hironori Kurachi ,  Masahiro Tamaru ,  Yoshikazu Hori ,  Mitsuru Takahashi ,  Takayuki Yoshida ,  Toshiyuki Sakai

发明人： Hisashi Kawasaki ,  Hiroyuki Abe ,  Kazuhide Hayakawa ,  Tetsuya Iida ,  Shinichi Kikuchi ,  Takayuki Yamaguchi ,  Toyomichi Nanayama ,  Hironori Kurachi ,  Masahiro Tamaru ,  Yoshikazu Hori ,  Mitsuru Takahashi ,  Takayuki Yoshida ,  Toshiyuki Sakai

IPC分类号： A61K31/519 ,  C07D239/545 ,  C07D471/04 ,  C07D487/04

CPC分类号： C07D471/04 ,  A61K31/519 ,  C07C275/30 ,  C07C275/50 ,  C07C2601/16 ,  C07D239/545 ,  C07D239/553 ,  C07D239/62 ,  C07D471/16 ,  C07D487/04 ,  C07F9/53

摘要： The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.

摘要翻译： 本发明涉及由下式[I]表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如说明书中所定义，以及治疗或预防性治疗不期望的细胞增殖的方法，包括施用这种化合物。 本发明的化合物在抑制不期望的细胞增殖，特别是抗肿瘤活性方面具有优异的活性，可用作预防或治疗癌症，风湿病等的抗肿瘤剂。 此外，当与其它抗肿瘤剂如烷化剂或代谢拮抗剂组合使用时，本发明的化合物可以是更有效的抗肿瘤剂。

公开(公告)号：US20060014768A1

公开(公告)日：2006-01-19

申请号：US11150792

申请日：2005-06-10

申请人： Hisashi Kawasaki ,  Hiroyuki Abe ,  Kazuhide Hayakawa ,  Tetsuya Iida ,  Shinichi Kikuchi ,  Takayuki Yamaguchi ,  Toyomichi Nanayama ,  Hironori Kurachi ,  Masahiro Tamaru ,  Yoshikazu Hori ,  Mitsuru Takahashi ,  Takayuki Yoshida ,  Toshiyuki Sakai

发明人： Hisashi Kawasaki ,  Hiroyuki Abe ,  Kazuhide Hayakawa ,  Tetsuya Iida ,  Shinichi Kikuchi ,  Takayuki Yamaguchi ,  Toyomichi Nanayama ,  Hironori Kurachi ,  Masahiro Tamaru ,  Yoshikazu Hori ,  Mitsuru Takahashi ,  Takayuki Yoshida ,  Toshiyuki Sakai

IPC分类号： A61K31/513 ,  C07D405/02

CPC分类号： C07D471/04 ,  A61K31/519 ,  C07C275/30 ,  C07C275/50 ,  C07C2601/16 ,  C07D239/545 ,  C07D239/553 ,  C07D239/62 ,  C07D471/16 ,  C07D487/04 ,  C07F9/53

摘要： The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.

摘要翻译： 本发明涉及由下式[I]表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如说明书中所定义，以及治疗或预防性治疗不期望的细胞增殖的方法，包括施用这种化合物。 本发明的化合物在抑制不期望的细胞增殖，特别是抗肿瘤活性方面具有优异的活性，可用作预防或治疗癌症，风湿病等的抗肿瘤剂。 此外，当与其它抗肿瘤剂如烷化剂或代谢拮抗剂组合使用时，本发明的化合物可以是更有效的抗肿瘤剂。

公开(公告)号：US20080312228A1

公开(公告)日：2008-12-18

申请号：US12053133

申请日：2008-03-21

申请人： Hisashi Kawasaki ,  Hiroyuki Abe ,  Kazuhide Hayakawa ,  Tetsuya Iida ,  Shinichi Kikuchi ,  Takayuki Yamaguchi ,  Toyomichi Nanayama ,  Hironori Kurachi ,  Masahiro Tamaru ,  Yoshikazu Hori ,  Mitsuru Takahashi ,  Takayuki Yoshida ,  Toshiyuki Sakai

发明人： Hisashi Kawasaki ,  Hiroyuki Abe ,  Kazuhide Hayakawa ,  Tetsuya Iida ,  Shinichi Kikuchi ,  Takayuki Yamaguchi ,  Toyomichi Nanayama ,  Hironori Kurachi ,  Masahiro Tamaru ,  Yoshikazu Hori ,  Mitsuru Takahashi ,  Takayuki Yoshida ,  Toshiyuki Sakai

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/496 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61K31/519 ,  C07C275/30 ,  C07C275/50 ,  C07C2601/16 ,  C07D239/545 ,  C07D239/553 ,  C07D239/62 ,  C07D471/16 ,  C07D487/04 ,  C07F9/53

摘要： The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.

摘要翻译： 本发明涉及由下式[I]表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如说明书中所定义，以及治疗或预防性治疗不期望的细胞增殖的方法，包括施用这种化合物。 本发明的化合物在抑制不期望的细胞增殖，特别是抗肿瘤活性方面具有优异的活性，可用作预防或治疗癌症，风湿病等的抗肿瘤剂。 此外，当与其它抗肿瘤剂如烷化剂或代谢拮抗剂组合使用时，本发明的化合物可以是更有效的抗肿瘤剂。

公开(公告)号：US20100240613A1

公开(公告)日：2010-09-23

申请号：US12626443

申请日：2009-11-25

申请人： Hisashi Kawasaki ,  Hiroyuki Abe ,  Kazuhide Hayakawa ,  Tetsuya Iida ,  Shinichi Kikuchi ,  Takayuki Yamaguchi ,  Toyomichi Nanayama ,  Hironori Kurachi ,  Masahiro Tamaru ,  Yoshikazu Hori ,  Mitsuru Takahashi ,  Takayuki Yoshida ,  Toshiyuki Sakai

发明人： Hisashi Kawasaki ,  Hiroyuki Abe ,  Kazuhide Hayakawa ,  Tetsuya Iida ,  Shinichi Kikuchi ,  Takayuki Yamaguchi ,  Toyomichi Nanayama ,  Hironori Kurachi ,  Masahiro Tamaru ,  Yoshikazu Hori ,  Mitsuru Takahashi ,  Takayuki Yoshida ,  Toshiyuki Sakai

IPC分类号： A61K31/675 ,  C07D471/04 ,  A61K31/519 ,  C07F9/53 ,  A61K31/5377 ,  C07D487/04 ,  C07C275/30 ,  C07C275/50 ,  C07D239/545 ,  A61P29/00 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61K31/519 ,  C07C275/30 ,  C07C275/50 ,  C07C2601/16 ,  C07D239/545 ,  C07D239/553 ,  C07D239/62 ,  C07D471/16 ,  C07D487/04 ,  C07F9/53

摘要： The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.

摘要翻译： 本发明涉及由下式[I]表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如说明书中所定义，以及治疗或预防性治疗不期望的细胞增殖的方法，包括施用这种化合物。 本发明的化合物在抑制不期望的细胞增殖，特别是抗肿瘤活性方面具有优异的活性，可用作预防或治疗癌症，风湿病等的抗肿瘤剂。 此外，当与其它抗肿瘤剂如烷化剂或代谢拮抗剂组合使用时，本发明的化合物可以是更有效的抗肿瘤剂。