发明申请
US20080317865A1 Quench liquids and washing systems for production of microparticles
审中-公开
用于生产微粒的骤冷液体和洗涤系统
- 专利标题： Quench liquids and washing systems for production of microparticles
- 专利标题（中）： 用于生产微粒的骤冷液体和洗涤系统
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申请号： US12140542申请日： 2008-06-17
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公开(公告)号： US20080317865A1公开(公告)日： 2008-12-25
- 发明人: Kristen Trapani , Paul Herbert
- 申请人： Kristen Trapani , Paul Herbert
- 申请人地址： US MA Cambridge
- 专利权人： ALKERMES, INC.
- 当前专利权人： ALKERMES, INC.
- 当前专利权人地址： US MA Cambridge
- 主分类号： A61K9/14
- IPC分类号： A61K9/14 ; A61K38/02 ; A61K38/16 ; A61K39/395 ; A61K38/20 ; A61K38/21 ; A61K38/14 ; A61K38/28 ; A61K38/43 ; A61K38/08 ; A61P43/00
摘要：
The present invention provides coacervation methods forming compositions for the sustained release water soluble active agents, including biologically active polypeptides. The invention further relates to the discovery of improved non-aqueous quench liquids and washing systems, which enable a reduction in the amount and concentration of hardening agents such as heptane used to produce microparticles, while providing acceptable product yields and residual solvent levels.
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