Invention Application
US20090023675A1 RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA)
有权
RNA干扰介导的使用化学修饰的短干扰核酸（siNA）的基因表达的抑制
- Patent Title: RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA)
- Patent Title (中): RNA干扰介导的使用化学修饰的短干扰核酸（siNA）的基因表达的抑制
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Application No.: US12105010Application Date: 2008-04-17
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Publication No.: US20090023675A1Publication Date: 2009-01-22
- Inventor: James McSwiggen , Bharat Chowrira , Leonid Beigelman , Dennis Macejak , Shawn Zinnen , Pamela Pavco , Peter Haeberli , David Morrissey , Kathy Fosnaugh , Sharon Jamison , Nassim Usman , James Thompson , Chandra Vargeese , Weimin Wang , Tongqian Chen , Narendra Vaish
- Applicant: James McSwiggen , Bharat Chowrira , Leonid Beigelman , Dennis Macejak , Shawn Zinnen , Pamela Pavco , Peter Haeberli , David Morrissey , Kathy Fosnaugh , Sharon Jamison , Nassim Usman , James Thompson , Chandra Vargeese , Weimin Wang , Tongqian Chen , Narendra Vaish
- Applicant Address: US CA San Francisco
- Assignee: SIRNA THERAPEUTICS, INC.
- Current Assignee: SIRNA THERAPEUTICS, INC.
- Current Assignee Address: US CA San Francisco
- Main IPC: A61K31/7088
- IPC: A61K31/7088 ; C07H21/00 ; A61P43/00
Abstract:
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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