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    RNA interference mediated inhibition of respiratory syncytial virus (RSV) expression using short interfering nucleic acid (siNA)
    2.
    发明申请
    RNA interference mediated inhibition of respiratory syncytial virus (RSV) expression using short interfering nucleic acid (siNA) 审中-公开
    使用短干扰核酸（siNA）的RNA干扰介导的呼吸道合胞病毒（RSV）表达的抑制

    公开(公告)号：US20060287267A1

    公开(公告)日：2006-12-21

    申请号：US11395833

    申请日：2006-03-31

    申请人： Narendra Vaish ,  Chandra Vargeese ,  James McSwiggen

    发明人： Narendra Vaish ,  Chandra Vargeese ,  James McSwiggen

    IPC分类号： A61K48/00 ,  A61K31/7056 ,  C07H21/02 ,  C07F9/6512

    CPC分类号： C12N15/1131 ,  C12N2310/14 ,  C12P19/34

    摘要： This invention relates to compounds, compositions, and methods useful for modulating sespiratory syncytial virus (RSV) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of RSV gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of RSV genes, including cocktails of such small nucleic acid molecules and lipid nanoparticle formulations of such such small nucleic acid molecules cocktails thereof. The application also relates to methods of treating diseases and conditions associated with RSV gene expression, such as RSV infection, respiratory failure, bronchiolitis and pneumonia, as well as providing dosing regimens and treatment protocols.

    摘要翻译： 本发明涉及使用短干扰核酸（siNA）分子调节呼吸道合胞病毒（RSV）基因表达的化合物，组合物和方法。 本发明还涉及用于通过使用小核酸分子调节参与RSV基因表达和/或通过RNA干扰（RNAi）的活性的其它基因的其他基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和方法用于调节RSV基因的表达，包括这种小核酸分子的混合物和这种这种小核酸分子的脂质纳米颗粒制剂的混合物。 该应用还涉及治疗与RSV基因表达相关的疾病和病症的方法，例如RSV感染，呼吸衰竭，细支气管炎和肺炎，以及提供给药方案和治疗方案。

    RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
    5.
    发明申请
    RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) 审中-公开
    RNA干扰介导的使用短干扰核酸（siNA）抑制血管内皮生长因子和血管内皮生长因子受体基因表达

    公开(公告)号：US20050233998A1

    公开(公告)日：2005-10-20

    申请号：US10944611

    申请日：2004-09-16

    申请人： Vasant Jadhav ,  Karl Kossen ,  Shawn Zinnen ,  Narendra Vaish ,  James McSwiggen

    发明人： Vasant Jadhav ,  Karl Kossen ,  Shawn Zinnen ,  Narendra Vaish ,  James McSwiggen

    IPC分类号： A01N43/04 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  C12P19/34

    CPC分类号： C12N15/113 ,  C12N2310/14

    摘要： This invention relates to compounds, compositions, and methods useful for modulating VEGF and/or VEGFR gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of VEGF and/or VEGFR gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (mRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of VEGF and/or VEGFR genes.

    摘要翻译： 本发明涉及使用短干扰核酸（siNA）分子调节VEGF和/或VEGFR基因表达的化合物，组合物和方法。 本发明还涉及使用小核酸分子调节参与VEGF和/或VEGFR基因表达和/或活性通过RNA干扰（RNAi）的其它基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（mRNA）和短发夹RNA（shRNA） ）分子和用于调节VEGF和/或VEGFR基因表达的方法。

    Inhibition of gene expression using duplex forming oligonucleotides
    6.
    发明申请
    Inhibition of gene expression using duplex forming oligonucleotides 审中-公开
    使用双链体形成寡核苷酸抑制基因表达

    公开(公告)号：US20050233329A1

    公开(公告)日：2005-10-20

    申请号：US10727780

    申请日：2003-12-03

    申请人： James McSwiggen ,  Narendra Vaish ,  Shawn Zinnen

    发明人： James McSwiggen ,  Narendra Vaish ,  Shawn Zinnen

    IPC分类号： C07H21/04 ,  C12Q1/68

    CPC分类号： C07H21/04 ,  C12Q1/6811 ,  C12Q2525/207 ,  C12Q2525/301

    摘要： The present invention concerns methods and nucleic acid based reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, veterinary, agricultural, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to double strand forming oligonucleotides (DFO) that can self assemble to form double stranded oligonucleotides, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA) molecules, and modulate gene expression, for example by RNA interference (RNAi). The self complementary DFO nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

    摘要翻译： 本发明涉及可用于调节各种应用中的基因表达的方法和基于核酸的试剂，包括在治疗，兽医，农业，诊断，靶标验证和基因组发现应用中的用途。 具体地，本发明涉及可以自组装形成双链寡核苷酸的双链形成寡核苷酸（DFO），例如短干扰核酸（siNA），短干扰RNA（siRNA）分子和调节基因表达，例如通过RNA 干扰（RNAi）。 自身互补的DFO核酸分子可用于治疗对细胞，组织或生物中的基因表达或活性的调节作出反应的任何疾病或病症。

    RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
    7.
    发明申请
    RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) 审中-公开
    RNA干扰介导的基因表达抑制使用短暂的干扰核酸（siNA）

    公开(公告)号：US20100145038A1

    公开(公告)日：2010-06-10

    申请号：US12615146

    申请日：2009-11-09

    申请人： James McSwiggen ,  Narendra Vaish

    发明人： James McSwiggen ,  Narendra Vaish

    IPC分类号： C07H21/02

    CPC分类号： C07H21/02

    摘要： This invention relates to compounds, compositions, and methods useful for modulating gene expression using short interfering nucleic acid (siNA) molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of genes, such as expressed pseudogenes associated with the maintenance or development of diseases, disorders, traits, and conditions in a subject or organism.

    摘要翻译： 本发明涉及可用于使用短干扰核酸（siNA）分子调节基因表达的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节基因表达的方法，例如与受试者或生物中的疾病，病症，性状和病症的维持或发展相关的表达的假基因。