发明申请
- 专利标题： Decoy Nucleic Acid to Synoviolin Gene Promoter
- 专利标题（中）： 诱饵核酸对滑膜蛋白基因启动子
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申请号： US10594146申请日： 2005-03-28
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公开(公告)号： US20090029929A1公开(公告)日： 2009-01-29
- 发明人: Toshihiro Nakajima , Kaneyuki Tsuchimochi , Naoko Yagishita , Satoshi Yamasaki , Yukihiro Kato , Tetsuya Amano , Kaori Tamitsu
- 申请人： Toshihiro Nakajima , Kaneyuki Tsuchimochi , Naoko Yagishita , Satoshi Yamasaki , Yukihiro Kato , Tetsuya Amano , Kaori Tamitsu
- 申请人地址： JP Yokohama-Shi
- 专利权人： Locomogene, Inc.
- 当前专利权人： Locomogene, Inc.
- 当前专利权人地址： JP Yokohama-Shi
- 优先权： JP2004-092570 20040326
- 国际申请： PCT/JP05/06527 WO 20050328
- 主分类号： A61K31/711
- IPC分类号： A61K31/711 ; A61K48/00 ; A61P19/02 ; A61P21/00 ; A61P25/00 ; A61P25/16 ; A61P25/28 ; A61P29/00 ; A61P35/00 ; C12N15/12 ; C12N5/10
摘要：
The present invention provides a decoy nucleic acid for the Synoviolin gene promoter. Also provided is the decoy nucleic acid can inhibit the promoter activity by binding to the transcription factor of the Synoviolin gene promoter. It also provides a decoy nucleic acid as expressed in (a) a decoy nucleic acid consisting of a nucleotide sequence as shown in SEQ ID NO: 11 or 12; and it also provides (b) a decoy nucleic acid consisting of a nucleotide sequence as shown in SEQ ID NO: 11 or 12 having deletion, substitution or addition of one or several nucleotides and has the function of inhibiting Synoviolin gene promoter activity.
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