摘要:
The present invention provides a decoy nucleic acid for the Synoviolin gene promoter. Also provided is the decoy nucleic acid can inhibit the promoter activity by binding to the transcription factor of the Synoviolin gene promoter. It also provides a decoy nucleic acid as expressed in (a) a decoy nucleic acid consisting of a nucleotide sequence as shown in SEQ ID NO: 11 or 12; and it also provides (b) a decoy nucleic acid consisting of a nucleotide sequence as shown in SEQ ID NO: 11 or 12 having deletion, substitution or addition of one or several nucleotides and has the function of inhibiting Synoviolin gene promoter activity.
摘要翻译:本发明提供了用于滑膜炎基因启动子的诱饵核酸。 还提供了诱饵核酸可以通过与滑膜素基因启动子的转录因子结合来抑制启动子活性。 它还提供如(a)由如SEQ ID NO:11或12所示的核苷酸序列组成的诱饵核酸所表达的诱饵核酸; 并且还提供(b)由SEQ ID NO:11或12所示的具有缺失,取代或添加一个或几个核苷酸的核苷酸序列组成的具有抑制滑膜素基因启动子活性的功能的诱饵核酸。
摘要:
The present invention provides a pharmaceutical composition containing a substance which inhibits the proliferation of synovial tissue or synovial cells and the interleukin-6 production. It also provides a pharmaceutical composition for inhibiting the proliferation of synovial tissue or synovial cells and the interleukin-6 production, which is useful for diagnosing and treating at least one selected from the group consisting of rheumatoid arthritis, fibrosis, arthritis, cancers, and cerebral neural diseases. In addition, it provides a method for inhibiting the proliferation of synovial cells and the interleukin-6 production by inhibiting the expression of hsHRD3 in synovial cells.
摘要:
The present invention provides a nerve cell differentiation inducing drug containing a Synoviolin expression inhibitor which is a useful drug for treatments of neural disorders, particularly Alzheimer's disease, Parkinson's disease, peripheral nerve disorders or spinal injury. As Synoviolin expression inhibitors, there are siRNA against gene coding Synoviolin (SEQ ID No. 1 or 2), or shRNA, a decoy nucleic acid that inhibits the promoter activity by binding to the transcription factor of the promoter of the Synoviolin gene or antisense oligonucleotide against gene coding the Synoviolin. The nerve cell differentiation inducing drug of the present invention is used for the treatment of neural disorders including Alzheimer's disease, Parkinson's disease, peripheral nerve disorders or spinal injury.
摘要翻译:本发明提供了含有滑膜素表达抑制剂的神经细胞分化诱导药物,其是治疗神经障碍,特别是阿尔茨海默氏病,帕金森病,周围神经障碍或脊髓损伤的有用药物。 作为滑膜素表达抑制剂,存在针对基因编码滑膜蛋白(SEQ ID No.1或2)的siRNA或shRNA,通过与滑膜炎基因或反义寡核苷酸启动子的转录因子结合来抑制启动子活性的诱饵核酸 针对基因编码Synoviolin。 本发明的神经细胞分化诱导药物用于治疗包括阿尔茨海默氏病,帕金森氏病,周围神经障碍或脊髓损伤的神经障碍。
摘要:
Inhibition of synoviolin function was found to activate the cancer-suppressing protein p53. Substances inhibiting the function of synoviolin are useful as cancer therapeutic agents. The inhibition of synoviolin function was also found to lead to the inhibition of p53 ubiquitination, increased activity of p53 phosphorylation proteins, and the like. Based on these findings, the present invention provides methods capable of efficiently screening for cancer therapeutic agents. Further, it was also found that regulation of the autoubiquitination of synoviolin protein suppresses the proliferation of rheumatoid arthritis synovial cells. Substances regulating the autoubiquitination of synoviolin protein are useful as anti-rheumatic agents. Moreover, the present invention provides methods of efficiently screening for anti-rheumatic agents.
摘要:
An angle detection apparatus includes a rotation member including at least one north magnetic polar region and at least one south magnetic polar region alternately arranged around a rotation center, a magnetic field detecting portion having a magnetic plate and detecting elements detecting magnitudes of magnetic components in a direction perpendicular to the magnetic plate, and a computing unit determining a rotation angle of the rotation member, wherein the magnetic field detecting portion is disposed so that the magnetic plate is oriented perpendicular to a first direction, where magnetic field intensity is at its maximum, and the magnetic field detecting portion detects the magnitudes of the magnetic components in the first direction and a second direction corresponding to a direction that the north and south magnetic polar regions are circumferentially arranged.
摘要:
Soldering flux compositions, solder pastes, and methods of soldering using the same are provided, that exhibit excellent wettability, give highly reliable solder joints, and have superior storage stability. The flux composition contains at least one compound having at least one blocked carboxyl group selected from the group including compound (X) obtained by reaction of a carboxylic acid compound and a vinyl ether compound, compound (Y) obtained by reaction of a carboxylic acid anhydride compound and a hydroxy vinyl ether compound, and compound (Z) obtained by reaction of an acid anhydride and a polyhydric alcohol, followed by addition polymerization with a divinyl ether compound, and the flux composition is non-curing.
摘要:
A rotation sensor has a sensor and a processing circuit that are provided as an integrated circuit chip (IC chip). The sensor has a magnetic resistance element. The rotation sensor senses an angular change of a magnetic vector as a change of resistance. The rotation sensor is located to face a rotor, or a helical gear used in an automatic transmission. The magnetic resistance element is located such that a sensing plane thereof is parallel to a hypothetical plane perpendicular to the line of inclination of each tooth of the rotor.
摘要:
An angular sensor which enables to obtain an output signal proportional to a relative rotational angle with low manufacturing cost and with miniaturized size. An angular sensor which includes a first magnet and a second magnet fixed to a rotation body, magnetic flux sensing surface is fixed to the stator to be positioned in magnetic field between the first magnet and the second magnet and perpendicular to magnetic sensing direction for sensing a magnetic flux, a magneto-electric transducer element for outputting an electric signal corresponding to a magnetic sensing direction element of the magnetic density, deflection yokes. The deflection yokes are positioned facing the magnetic flux sensing surfaces. The deflection yokes are positioned within a range of three quarters of a distance between the first magnet and the second magnet in X-axis direction and one half of a distance between the first magnet and the second magnet in Y-axis direction.
摘要:
The full bridge circuit in a pressure sensor including semiconductor piezoelectric resistive elements in a pressure detection structure is connected to a filter. That is, first and second output terminals of the full bridge circuit is connected to a capacitor. One end of the capacitor is connected to the first output terminal through a first resistor. The other end of the capacitor is connected to the second output terminal through a second resistor. In an exhaust system of an engine, the pressure of the exhaust gas is detected to detect clogging in the black smoke removing unit. The filter removes the pulsate component in the detection signal derived from the pulsate component in the exhaust gas.
摘要:
A variable resistor includes a first housing, a second housing formed of resin and having a connector part and a circuit board whose surface has an electrode and a resistance pattern thereon. A metallic terminal is molded in the second housing as one body and a brush is mounted on a moving member and is disposed in sliding engagement with the resistance pattern. An end of the terminal is in contact with the electrode on the surface of the circuit board and the other end of the terminal is disposed in the connector part.