公开(公告)号：US20090029929A1

公开(公告)日：2009-01-29

申请号：US10594146

申请日：2005-03-28

申请人： Toshihiro Nakajima ,  Kaneyuki Tsuchimochi ,  Naoko Yagishita ,  Satoshi Yamasaki ,  Yukihiro Kato ,  Tetsuya Amano ,  Kaori Tamitsu

发明人： Toshihiro Nakajima ,  Kaneyuki Tsuchimochi ,  Naoko Yagishita ,  Satoshi Yamasaki ,  Yukihiro Kato ,  Tetsuya Amano ,  Kaori Tamitsu

IPC分类号： A61K31/711 ,  A61K48/00 ,  A61P19/02 ,  A61P21/00 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  C12N15/12 ,  C12N5/10

CPC分类号： C12N15/113 ,  A61K31/7088 ,  A61K48/00 ,  C12N2310/13

摘要： The present invention provides a decoy nucleic acid for the Synoviolin gene promoter. Also provided is the decoy nucleic acid can inhibit the promoter activity by binding to the transcription factor of the Synoviolin gene promoter. It also provides a decoy nucleic acid as expressed in (a) a decoy nucleic acid consisting of a nucleotide sequence as shown in SEQ ID NO: 11 or 12; and it also provides (b) a decoy nucleic acid consisting of a nucleotide sequence as shown in SEQ ID NO: 11 or 12 having deletion, substitution or addition of one or several nucleotides and has the function of inhibiting Synoviolin gene promoter activity.

摘要翻译： 本发明提供了用于滑膜炎基因启动子的诱饵核酸。 还提供了诱饵核酸可以通过与滑膜素基因启动子的转录因子结合来抑制启动子活性。 它还提供如（a）由如SEQ ID NO：11或12所示的核苷酸序列组成的诱饵核酸所表达的诱饵核酸; 并且还提供（b）由SEQ ID NO：11或12所示的具有缺失，取代或添加一个或几个核苷酸的核苷酸序列组成的具有抑制滑膜素基因启动子活性的功能的诱饵核酸。

公开(公告)号：US20080070298A1

公开(公告)日：2008-03-20

申请号：US10569330

申请日：2004-08-23

申请人： Toshihiro Nakajima ,  Tetsuya Amano ,  Satoshi Yamasaki ,  Naoko Yagishita ,  Kaneyuki Tsuchimochi

发明人： Toshihiro Nakajima ,  Tetsuya Amano ,  Satoshi Yamasaki ,  Naoko Yagishita ,  Kaneyuki Tsuchimochi

IPC分类号： C12N5/10 ,  C07H21/00 ,  C12N1/00 ,  C12N15/63

CPC分类号： C07K14/47

摘要： The present invention provides a promoter of the synoviolin gene comprising at least the nucleotide sequence of nucleotides 2120-2130 in the nucleotide sequence represented by SEQ ID: NO 1 or 2, or comprising at least the nucleotide sequence of the region of nucleotides 1-2201, 969-2201, 1142-2201, 1699-2201, 1880-2201, 2002-2201, 2094-2201 or 2118-2201 in the nucleotide sequence represented by SEQ ID: NO 1 or 2;or a method for regulating transcription activity characterized in that the activity of the promoter is inhibited or enhanced.

摘要翻译： 本发明提供滑膜蛋白基因的启动子，其至少包含由SEQ ID NO：1所示的核苷酸序列中的核苷酸2120-2130的核苷酸序列，或者至少包含核苷酸区域的核苷酸序列1-2201 ，969-2201,1142-2201,1699-2201,1880-2201,2002-2201,2094-2201或2118-2201所示的核苷酸序列;或调节转录活性的方法，其特征在于 因为启动子的活性被抑制或增强。