发明申请
- 专利标题： Rhodanine Derivatives, a Process for the Preparation Thereof and Pharmaceutical Composition Containing the Same
- 专利标题（中）： 罗丹明衍生物，其制备方法和含有其的药物组合物
-
申请号： US12087474申请日： 2006-12-08
-
公开(公告)号： US20090042872A1公开(公告)日： 2009-02-12
- 发明人: Seong Eon Ryu , Seung Jun Kim , Dae Gwin Jeong , Sang Hyeup Lee , Suk Kyeong Jung , Hwan Mook Kim , Song Kyu Park , Ki Ho Lee , Chang Woo Lee , Joong-Kwon Choi , Jin Hee Ahn
- 申请人： Seong Eon Ryu , Seung Jun Kim , Dae Gwin Jeong , Sang Hyeup Lee , Suk Kyeong Jung , Hwan Mook Kim , Song Kyu Park , Ki Ho Lee , Chang Woo Lee , Joong-Kwon Choi , Jin Hee Ahn
- 申请人地址： KR Daejeon KR Taejeon-si
- 专利权人： Korea Research Institute of Bioscience and Biotechnology,Korea Research Institute of Chemical Technology
- 当前专利权人： Korea Research Institute of Bioscience and Biotechnology,Korea Research Institute of Chemical Technology
- 当前专利权人地址： KR Daejeon KR Taejeon-si
- 优先权： KR10-2006-0002175 20060109
- 国际申请： PCT/KR2006/005343 WO 20061208
- 主分类号： A61K31/426
- IPC分类号： A61K31/426 ; C07D277/04 ; C07D413/12 ; A61K31/538 ; A61P3/10 ; A61P35/00 ; A61P3/04 ; A61K31/5377 ; C07D265/34
摘要：
Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTP1B, Prl-3, LAR, CD45, Cdc25A, Cdc25B, Cdc25C, Yop, PP1 and VHR, and can be applied for the prevention and treatment of PPase-caused diseases, including autoimmune diseases, diabetes, impaired glucose intolerance, insulin resistance, obesity, cancers, etc. when the inhibitory activity thereof is modulated.