公开(公告)号：US20230339871A1

公开(公告)日：2023-10-26

申请号：US18022117

申请日：2021-08-18

Applicant: METREA BIOSCIENCES, INC.

Inventor： Paul Da Silva Jardine ,  Frederick Dewey ,  Joshua Hoffman

IPC: C07D277/04 ,  C07D417/06 ,  A61K31/4439 ,  A61K31/426 ,  C07D333/22 ,  A61K31/381 ,  C07D413/06 ,  A61K31/4178 ,  C07D215/48 ,  C07D401/12 ,  A61K31/4709 ,  A61K31/4704 ,  C07D263/06 ,  C07D217/26 ,  A61K31/47 ,  A61P1/16 ,  A61K31/4166 ,  A61K31/427 ,  A61K45/06

CPC classification number: C07D277/04 ,  C07D417/06 ,  A61K31/4439 ,  A61K31/426 ,  C07D333/22 ,  A61K31/381 ,  C07D413/06 ,  A61K31/4178 ,  C07D215/48 ,  C07D401/12 ,  A61K31/4709 ,  A61K31/4704 ,  C07D263/06 ,  C07D217/26 ,  A61K31/47 ,  A61P1/16 ,  A61K31/4166 ,  A61K31/427 ,  A61K45/06

Abstract: The present disclosure is generally directed to modulators of hydroxysteroid dehydrogenase enzymes useful in the treatment of diseases and disorders modulated by said enzyme and having the Formula (I), Formula (II), or Formula (III).

公开(公告)号：US11661580B2

公开(公告)日：2023-05-30

申请号：US17006338

申请日：2020-08-28

Applicant: Cassava Science, Inc.

Inventor： Hoau-Yan Wang ,  Lindsay Burns Barbier

IPC: C12N5/079 ,  C07D265/30 ,  C07D211/14 ,  C07D277/04 ,  C07D295/088 ,  C07D205/04 ,  C07D491/056 ,  C07D498/10 ,  C07D217/04 ,  C07D471/10 ,  C07D491/04 ,  C07D207/08 ,  C07D265/36 ,  C07D277/02 ,  C07D279/12 ,  C07D295/08 ,  C07D211/74 ,  G01N33/50 ,  G01N33/68 ,  G01N33/94

CPC classification number: C12N5/0622 ,  C07D205/04 ,  C07D207/08 ,  C07D211/14 ,  C07D211/74 ,  C07D217/04 ,  C07D265/30 ,  C07D265/36 ,  C07D277/02 ,  C07D277/04 ,  C07D279/12 ,  C07D295/08 ,  C07D295/088 ,  C07D471/10 ,  C07D491/04 ,  C07D491/056 ,  C07D498/10 ,  G01N33/50 ,  G01N33/6896 ,  G01N33/94 ,  G01N2333/70571 ,  G01N2800/2821 ,  G01N2800/52

Abstract: A method of inhibiting phosphorylation of the tau protein and/or a TLR4-mediated immune response is disclosed. The method contemplates administering to cells in recognized need thereof such as cells of the central nervous system an effective amount of a of a compound or a pharmaceutically acceptable salt thereof that binds to a pentapeptide of filamin A (FLNA) of SEQ ID NO: 1, and contains at least four of the six pharmacophores of FIGS. 35-40.

公开(公告)号：US10774040B1

公开(公告)日：2020-09-15

申请号：US16396820

申请日：2019-04-29

Applicant: Chevron Phillips Chemical Company LP

Inventor： Kenneth M. Lassen ,  Michael S. Matson ,  Daniel M. Hasenberg ,  Dave Schwierman

IPC: C07C319/28 ,  C07C319/14 ,  C07C319/06 ,  B01J8/02 ,  C07D277/04 ,  B01D3/02 ,  C07D263/22 ,  C07D263/16 ,  B01D3/00

Abstract: Processes for removing carbon disulfide from product streams containing a sulfide compound are performed by contacting the product stream with an alkanolamine and converting the carbon disulfide to a higher boiling point product, thereby reducing or eliminating carbon disulfide from the product stream. Subsequent removal of the higher boiling point product via distillation can lead to a purified sulfide stream with high purity.

公开(公告)号：US20170369468A1

公开(公告)日：2017-12-28

申请号：US15694439

申请日：2017-09-01

Applicant: The Regents of the University of California

Inventor： Anandasankar Ray ,  Christine Krause Pham ,  Sean Michael Boyle

IPC: C07D335/02 ,  C07D317/20 ,  C07D277/04 ,  C07D215/06 ,  C07D207/26 ,  C07D207/16 ,  C07C13/23 ,  C07C13/20 ,  A01N43/78 ,  A01N43/42 ,  A01N43/36 ,  A01N43/32 ,  A01N43/28 ,  A01N43/26 ,  A01N43/20 ,  A01N43/16 ,  A01N43/08 ,  A01N35/06 ,  A01N31/04 ,  A01N27/00 ,  C07D319/06 ,  C07C2601/16

CPC classification number: C07D335/02 ,  A01N27/00 ,  A01N31/04 ,  A01N35/06 ,  A01N43/08 ,  A01N43/16 ,  A01N43/20 ,  A01N43/26 ,  A01N43/28 ,  A01N43/32 ,  A01N43/36 ,  A01N43/42 ,  A01N43/78 ,  C07C13/20 ,  C07C13/23 ,  C07C2601/16 ,  C07D207/16 ,  C07D207/26 ,  C07D215/06 ,  C07D277/04 ,  C07D317/20 ,  C07D319/06

Abstract: Compositions and methods for repelling arthropods. The compositions include a carrier and an arthropod repelling compound, which can be a compound discovered by a novel and complex cheminformatic process to demonstrate repellency behavior across a broad spectrum of arthropods. The compound can be a thiane compound, a pyrrolidone compound, a cyclohexadiene compound, a cyclohexenone compound, a cyclohexene compound, a furanone compound, a pyran compound, a tetrahydropyran compound, a thiazolidine compound, a thiazoline compound, a dihydrothiophene compound, a dithiolane compound, a dithiane compound, an epoxide compound, an oxathiane compound, a cyclopentene compound, a cyclohexane compound, a quinoline compound, an oxazoline compound, a tetrahydropyridine compound, and an imidazolidinone compound, or a combination thereof.

公开(公告)号：US20160272612A1

公开(公告)日：2016-09-22

申请号：US15073698

申请日：2016-03-18

Applicant: The Regents of the University of California

Inventor： Anandasankar Ray ,  Christine Krause Pham ,  Sean Michael Boyle

IPC: C07D335/02 ,  C07D207/26 ,  C07D207/16 ,  A01N43/18 ,  A01N43/28 ,  C07D317/20 ,  A01N43/32 ,  C07D319/06 ,  A01N27/00 ,  C07C13/20 ,  A01N35/06 ,  C07C49/713 ,  A01N31/04 ,  C07C35/18 ,  A01N43/78 ,  C07D277/04 ,  A01N43/42 ,  C07D215/06 ,  A01N43/36

CPC classification number: C07D335/02 ,  A01N27/00 ,  A01N31/04 ,  A01N35/06 ,  A01N43/08 ,  A01N43/16 ,  A01N43/20 ,  A01N43/26 ,  A01N43/28 ,  A01N43/32 ,  A01N43/36 ,  A01N43/42 ,  A01N43/78 ,  C07C13/20 ,  C07C13/23 ,  C07C2601/16 ,  C07D207/16 ,  C07D207/26 ,  C07D215/06 ,  C07D277/04 ,  C07D317/20 ,  C07D319/06

Abstract: Compositions and methods for repelling arthropods. The compositions include a carrier and an arthropod repelling compound, which can be a compound discovered by a novel and complex cheminformatic process to demonstrate repellency behavior across a broad spectrum of arthropods. The compound can be a thiane compound, a pyrrolidone compound, a cyclohexadiene compound, a cyclohexenone compound, a cyclohexene compound, a furanone compound, a pyran compound, a tetrahydropyran compound, a thiazolidine compound, a thiazoline compound, a dihydrothiophene compound, a dithiolane compound, a dithiane compound, an epoxide compound, an oxathiane compound, a cyclopentene compound, a cyclohexane compound, a quinoline compound, an oxazoline compound, a tetrahydropyridine compound, and an imidazolidinone compound, or a combination thereof.

Abstract translation: 组织和排斥节肢动物的方法。 组合物包括载体和节肢动物排斥化合物，其可以是通过新颖和复杂的化学信息过程发现的化合物，以证明广泛节肢动物的驱避行为。 化合物可以是噻吩化合物，吡咯烷酮化合物，环己二烯化合物，环己烯酮化合物，环己烯化合物，呋喃酮化合物，吡喃化合物，四氢吡喃化合物，噻唑烷化合物，噻唑啉化合物，二氢噻吩化合物，二硫戊环 化合物，二噻烷化合物，环氧化合物，氧硫杂环戊烯化合物，环戊烯化合物，环己烷化合物，喹啉化合物，恶唑啉化合物，四氢吡啶化合物和咪唑啉酮化合物或其组合。

公开(公告)号：US09428477B2

公开(公告)日：2016-08-30

申请号：US14395241

申请日：2013-04-26

Applicant: NIPPON ZOKI PHARMACEUTICAL CO., LTD. ,  NAGOYA INDUSTRIAL SCIENCE RESEARCH INSTITUTE

Inventor： Munekazu Iinuma ,  Shoei Furukawa ,  Mitsuru Naiki ,  Tomonori Matsumoto ,  Kunihiko Higashiura

IPC: C07D207/08 ,  C07D295/185 ,  C07D213/74 ,  C07D239/42 ,  C07D243/08 ,  C07D207/16 ,  C07D277/04 ,  C07D211/16 ,  C07D211/18 ,  C07D211/26 ,  C07D211/30 ,  C07D211/44 ,  C07D211/46 ,  C07D211/48 ,  C07D211/58 ,  C07D211/62 ,  C07D295/18 ,  C07D211/74

CPC classification number: C07D295/185 ,  C07D207/08 ,  C07D207/16 ,  C07D211/16 ,  C07D211/18 ,  C07D211/26 ,  C07D211/30 ,  C07D211/44 ,  C07D211/46 ,  C07D211/48 ,  C07D211/58 ,  C07D211/62 ,  C07D211/74 ,  C07D213/74 ,  C07D239/42 ,  C07D243/08 ,  C07D277/04 ,  C07D295/18

Abstract: The present invention relates to a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical agent containing the compound as an active ingredient. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt, which is the compound of the present invention, is specifically represented by the general formula (I): wherein X is a substituent such as a 1-pyrrolidyl, a 3-thiazolizyl, or a piperidino, and the compound is highly useful as a pharmaceutical agent, such as a prophylactic or therapeutic agent for a peripheral nerve disorder induced by administration of an anticancer agent, a prophylactic or therapeutic agent for neurodegenerative diseases or mental diseases such as dementia, Alzheimer's disease, Parkinson's disease, diabetic neuropathy, depression, glaucoma, or autistic disorder spectrum, a therapeutic or repairing agent for spinal cord injury, analgesics against various pain diseases, or the like.

Abstract translation: 本发明涉及新的反式-2-癸烯酸衍生物或其药学上可接受的盐，以及含有该化合物作为活性成分的药剂。 作为本发明化合物的反式-2-癸烯酸衍生物或药学上可接受的盐，具体地由通式（I）表示：其中X是取代基，例如1-吡咯烷基，3-噻唑基 或哌啶子基，并且该化合物作为药剂非常有用，例如通过施用抗癌剂诱导的周围神经障碍的预防或治疗剂，用于神经变性疾病或精神疾病如痴呆的预防或治疗剂 阿尔茨海默病，帕金森病，糖尿病性神经病，抑郁症，青光眼，自闭症病症谱，脊髓损伤用治疗剂或修复剂，各种疼痛疾病的镇痛剂等。

公开(公告)号：US09309278B2

公开(公告)日：2016-04-12

申请号：US14116623

申请日：2012-05-14

Applicant: Chuan-Fa Liu ,  Fupeng Li

Inventor： Chuan-Fa Liu ,  Fupeng Li

IPC: C07K1/113 ,  C07C323/12 ,  C07C323/25 ,  C07C319/18 ,  C07K1/107 ,  C07C69/533 ,  C07C233/05 ,  C07K14/00 ,  C07D277/04 ,  C07D277/06

CPC classification number: C07K1/113 ,  C07C69/533 ,  C07C233/05 ,  C07C319/18 ,  C07D277/04 ,  C07D277/06 ,  C07K1/1077 ,  C07K14/00 ,  G01N2440/10 ,  G01N2440/12 ,  C07C323/41

Abstract: The present invention is directed to a method of alkylating a thiol group (R—S—H) or seleno group (R—Se—H) in a target molecule wherein the method comprises: reacting a target molecule comprising at least one thiol group with a compound of formula (I) or (II): wherein R is an acetyl group or any other acyl group or is a group comprising any one of: or wherein R in formula (II) can also be an alkyl group; and wherein R′ is selected from a group consisting of a hydrogen, a methyl group and an ethyl group. In certain cases, the described methods may be used to install acetylated lysine analogs in target molecules (e.g., peptides, proteins).

Abstract translation: 本发明涉及在目标分子中烷基化硫醇基（R-S-H）或硒基（R-Se-H）的方法，其中所述方法包括：将包含至少一个硫醇基的靶分子与 式（I）或（II）的化合物：其中R是乙酰基或任何其它酰基，或是包含以下任何一种的基团：或其中式（II）中的R也可以是烷基; 并且其中R'选自氢，甲基和乙基。 在某些情况下，所描述的方法可用于在靶分子（例如肽，蛋白质）中安装乙酰化的赖氨酸类似物。

公开(公告)号：US09045444B2

公开(公告)日：2015-06-02

申请号：US14195666

申请日：2014-03-03

Applicant: AbbVie Inc.

Inventor： Hong Ding ,  Christopher L. Lynch ,  Xiaohong Song ,  Xilu Wang ,  Michael D. Wendt

IPC: C07D451/02 ,  C07D205/04 ,  C07D207/04 ,  C07D211/20 ,  C07D213/38 ,  C07D215/12 ,  C07D231/12 ,  C07D233/06 ,  C07D239/38 ,  C07D241/04 ,  C07D249/18 ,  C07D401/10 ,  C07D295/155 ,  C07D207/06 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D207/20 ,  C07D207/24 ,  C07D207/50 ,  C07D211/14 ,  C07D211/26 ,  C07D211/34 ,  C07D211/38 ,  C07D211/42 ,  C07D211/46 ,  C07D211/48 ,  C07D211/58 ,  C07D211/62 ,  C07D211/70 ,  C07D211/72 ,  C07D213/36 ,  C07D213/42 ,  C07D213/70 ,  C07D213/74 ,  C07D213/81 ,  C07D213/82 ,  C07D231/56 ,  C07D233/61 ,  C07D233/64 ,  C07D235/08 ,  C07D239/06 ,  C07D257/04 ,  C07D261/20 ,  C07D263/12 ,  C07D263/22 ,  C07D263/58 ,  C07D265/30 ,  C07D267/10 ,  C07D273/01 ,  C07D277/36 ,  C07D277/74 ,  C07D295/185 ,  C07D295/30 ,  C07D307/14 ,  C07D307/22 ,  C07D307/81 ,  C07D309/14 ,  C07D309/20 ,  C07D317/66 ,  C07D333/20 ,  C07D333/34 ,  C07D335/02 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/10 ,  C07D413/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08 ,  C07D491/04 ,  C07D491/08 ,  C07D498/08 ,  C07C311/51 ,  C07D207/09 ,  C07D209/02 ,  C07D233/24 ,  C07D239/20 ,  C07D277/04 ,  C07D491/048 ,  C07D209/52 ,  C07D233/22

CPC classification number: C07D295/155 ,  C07C311/51 ,  C07D205/04 ,  C07D207/06 ,  C07D207/08 ,  C07D207/09 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D207/20 ,  C07D207/24 ,  C07D207/50 ,  C07D209/02 ,  C07D209/52 ,  C07D211/14 ,  C07D211/20 ,  C07D211/26 ,  C07D211/34 ,  C07D211/38 ,  C07D211/42 ,  C07D211/46 ,  C07D211/48 ,  C07D211/58 ,  C07D211/62 ,  C07D211/70 ,  C07D211/72 ,  C07D213/36 ,  C07D213/38 ,  C07D213/42 ,  C07D213/70 ,  C07D213/74 ,  C07D213/81 ,  C07D213/82 ,  C07D215/12 ,  C07D231/12 ,  C07D231/56 ,  C07D233/06 ,  C07D233/22 ,  C07D233/24 ,  C07D233/61 ,  C07D233/64 ,  C07D235/08 ,  C07D239/06 ,  C07D239/20 ,  C07D239/38 ,  C07D241/04 ,  C07D249/18 ,  C07D257/04 ,  C07D261/20 ,  C07D263/12 ,  C07D263/22 ,  C07D263/58 ,  C07D265/30 ,  C07D267/10 ,  C07D273/01 ,  C07D277/04 ,  C07D277/36 ,  C07D277/74 ,  C07D295/185 ,  C07D295/30 ,  C07D307/14 ,  C07D307/22 ,  C07D307/81 ,  C07D309/14 ,  C07D309/20 ,  C07D317/66 ,  C07D333/20 ,  C07D333/34 ,  C07D335/02 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/10 ,  C07D413/04 ,  C07D451/02 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08 ,  C07D491/04 ,  C07D491/048 ,  C07D491/08 ,  C07D498/08

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.

Abstract translation: 公开了抑制抗凋亡蛋白家族成员的活性的化合物，含有化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生表达一种或多种抗凋亡蛋白家族成员。

公开(公告)号：US09040525B2

公开(公告)日：2015-05-26

申请号：US13877626

申请日：2011-10-11

Applicant: Akihiro Okano ,  Munetaka Ohkouchi ,  Muneyoshi Makabe

Inventor： Akihiro Okano ,  Munetaka Ohkouchi ,  Muneyoshi Makabe

IPC: C07D279/02 ,  A61K31/541 ,  C07D277/04 ,  C07D275/02 ,  C07D285/10 ,  C07D285/16 ,  C07D417/12 ,  A61K31/425 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/549 ,  A61K45/06 ,  C07D285/34 ,  C07D417/14

CPC classification number: C07D417/12 ,  A61K31/4152 ,  A61K31/425 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/54 ,  A61K31/541 ,  A61K31/549 ,  A61K45/06 ,  C07D275/02 ,  C07D275/03 ,  C07D277/04 ,  C07D279/02 ,  C07D285/10 ,  C07D285/16 ,  C07D285/34 ,  C07D417/14

Abstract: [Problem]To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogues and a prophylactic and/or therapeutic agent against diabetes, obesity, or other diseases.[Means of Solving the Problem]A compound of Formula (1): (where n is 0 to 2; p is 0 to 4; h is 0 to 3; j is 0 to 3; k is 0 to 2; a ring B is an aryl group or a heteroaryl group; X is O, S, or —NR7—; J1 is —CR11aR11b— or —NR11c—; J2 is —CR12aR12b— or —NR12c—; and R1 to R12c are specific groups), a salt of the compound, or a solvate of the salt or the compound.

Abstract translation: 本发明提供具有GPR40激动剂作用的新化合物，化合物的盐，盐或化合物等的溶剂合物作为活性成分的GPR40活化剂，特别是胰岛素促分泌素和 用于预防和/或治疗糖尿病，肥胖或其它疾病的药物。 解决问题的方法式（1）的化合物：（其中n为0〜2; p为0〜4; h为0〜3; j为0〜3; k为0〜2;环B 是芳基或杂芳基; X是O，S或-NR7-; J1是-CR11aR11b-或-NR11c-; J2是-CR12aR12b-或-NR12c-，R1至R12c是特定基团），a 化合物的盐或盐或化合物的溶剂化物。

公开(公告)号：US08815922B2

公开(公告)日：2014-08-26

申请号：US13366602

申请日：2012-02-06

Applicant: Gary D. Crouse ,  Thomas C. Sparks ,  William H. Dent, III ,  CaSandra L. McLeod ,  Lawrence C. Creemer ,  David A. Demeter ,  Amanda E. Fritz ,  Lindsey G. Fischer ,  Erich W. Baum

Inventor： Gary D. Crouse ,  Thomas C. Sparks ,  William H. Dent, III ,  CaSandra L. McLeod ,  Lawrence C. Creemer ,  David A. Demeter ,  Amanda E. Fritz ,  Lindsey G. Fischer ,  Erich W. Baum

IPC: A61K31/427 ,  A61K31/422 ,  C07D263/30 ,  C07D277/04

CPC classification number: A01N43/60 ,  A01N43/653 ,  A01N43/72 ,  A01N43/76 ,  A01N43/78 ,  A01N43/80 ,  A01N43/86 ,  A01N43/90 ,  A01N47/34 ,  A01N47/42 ,  A61K45/06 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D495/04 ,  C07F7/0812

Abstract: This document discloses molecules having the following formulas (“Formula One” & “Formula Two” and “Formula Three”) The Ar1, Het, Ar2, R1, R2, R3, R4, and R5 are further described herein.

Abstract translation: 该文献公开了具有下式（“一级”，“二式”和“式三”）的分子。本文进一步描述了Ar1，Het，Ar2，R1，R2，R3，R4和R5。