公开(公告)号：US08148541B2

公开(公告)日：2012-04-03

申请号：US12087474

申请日：2006-12-08

申请人： Seong Eon Ryu ,  Seung Jun Kim ,  Dae Gwin Jeong ,  Sang Hyeup Lee ,  Suk Kyeong Jung ,  Hwan Mook Kim ,  Song Kyu Park ,  Ki Ho Lee ,  Chang Woo Lee ,  Joong-Kwon Choi ,  Jin Hee Ahn

发明人： Seong Eon Ryu ,  Seung Jun Kim ,  Dae Gwin Jeong ,  Sang Hyeup Lee ,  Suk Kyeong Jung ,  Hwan Mook Kim ,  Song Kyu Park ,  Ki Ho Lee ,  Chang Woo Lee ,  Joong-Kwon Choi ,  Jin Hee Ahn

IPC分类号： C07D277/04 ,  C07D417/02 ,  C07D413/02 ,  A61K31/535 ,  A61K31/497 ,  A61K31/425

CPC分类号： C07D277/20 ,  C07D417/12

摘要： Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTP1B, Prl-3, LAR, CD45, Cdc25A, Cdc25B, Cdc25C, Yop, PP1 and VHR, and can be applied for the prevention and treatment of PPase-caused diseases, including autoimmune diseases, diabetes, impaired glucose intolerance, insulin resistance, obesity, cancers, etc. when the inhibitory activity thereof is modulated.

摘要翻译： 本文公开了绕丹宁衍生物，其制备方法和含有它们的药物组合物。 罗丹明衍生物对PTP1B，Prl-3，LAR，CD45，Cdc25A，Cdc25B，Cdc25C，Yop，PP1和VHR等蛋白磷酸酶（PPase）具有抑制活性，可用于预防和治疗PPase引起的疾病 包括自身免疫性疾病，糖尿病，葡萄糖耐受不良，胰岛素抵抗，肥胖，癌症等。

公开(公告)号：US20120252996A1

公开(公告)日：2012-10-04

申请号：US13394896

申请日：2010-05-05

申请人： Jin Ku Cho ,  Sang Yong Kim ,  Do Hoon Lee ,  Bo Ra Kim ,  Baek Jin Kim ,  Jae Won Jung ,  Sang Hyeup Lee ,  Jae Soung Lee

发明人： Jin Ku Cho ,  Sang Yong Kim ,  Do Hoon Lee ,  Bo Ra Kim ,  Baek Jin Kim ,  Jae Won Jung ,  Sang Hyeup Lee ,  Jae Soung Lee

IPC分类号： C09J171/00 ,  C08G65/22 ,  C08G59/00 ,  C07D493/08 ,  C08F24/00

CPC分类号： C07D493/08 ,  A61K31/06 ,  C08F2/48 ,  C08G59/04

摘要： The present invention relates to a curable bicyclic compound derived from biomass, solvent-free curable composition and a method for preparing thereof. The curable compound derived from biomass according to the invention comprises a bicycle structure, to which one of two epoxide functional groups are bonded.

摘要翻译： 本发明涉及一种衍生自生物质的可固化双环化合物，无溶剂的可固化组合物及其制备方法。 根据本发明的由生物质得到的可固化化合物包含两个环氧官能团之一键合的自行车结构。

公开(公告)号：US09035018B2

公开(公告)日：2015-05-19

申请号：US13394910

申请日：2010-05-11

申请人： Jin Ku Cho ,  Sang Yong Kim ,  Do Hoon Lee ,  Bo Ra Kim ,  Baek Jin Kim ,  Jae Won Jung ,  Sang Hyeup Lee ,  Jae Soung Lee

发明人： Jin Ku Cho ,  Sang Yong Kim ,  Do Hoon Lee ,  Bo Ra Kim ,  Baek Jin Kim ,  Jae Won Jung ,  Sang Hyeup Lee ,  Jae Soung Lee

IPC分类号： C08G59/02 ,  C07D407/14 ,  C08F2/48 ,  C08G65/00

CPC分类号： C07D407/14 ,  C08F2/48 ,  C08G59/26

摘要： The present invention relates to a furan-based curable compound derived from carbohydrate-based biomass, to a solvent-free curable composition, and to a method for preparing thereof, wherein the furan-based curable compound derived from biomass according to the present invention includes two epoxide functional groups bonded to at least one furan-based compound. The present invention may provide an environmentally friendly next-generation curable compound comprising a novel furan-based compound derived from biomass, which may be substituted for curable materials derived from oil resources, as a basic backbone, as well as a composition containing the same. According to the present invention, a curable material, which has a low contraction ratio during curing as compared to conventional radical-type curing materials, may be obtained, and a compound applied to the novel curing material may be prepared with a combination of excellent efficiency and cost-effectiveness.

摘要翻译： 本发明涉及一种衍生自碳水化合物的生物质的呋喃类固化性化合物，无溶剂的可固化组合物及其制备方法，其中衍生自本发明的生物质的呋喃类固化性化合物包括 两个与至少一种呋喃基化合物键合的环氧官能团。 本发明可以提供一种环保的下一代可固化化合物，其包含衍生自生物质的新型呋喃基化合物，其可以替代源自石油资源的可固化材料作为基本骨架，以及含有该衍生物的组合物。 根据本发明，可以获得与常规自由基固化材料相比在固化期间具有低收缩率的可固化材料，并且可以以优异的效率组合来制备应用于新型固化材料的化合物 和成本效益。

公开(公告)号：US20090042872A1

公开(公告)日：2009-02-12

申请号：US12087474

申请日：2006-12-08

申请人： Seong Eon Ryu ,  Seung Jun Kim ,  Dae Gwin Jeong ,  Sang Hyeup Lee ,  Suk Kyeong Jung ,  Hwan Mook Kim ,  Song Kyu Park ,  Ki Ho Lee ,  Chang Woo Lee ,  Joong-Kwon Choi ,  Jin Hee Ahn

发明人： Seong Eon Ryu ,  Seung Jun Kim ,  Dae Gwin Jeong ,  Sang Hyeup Lee ,  Suk Kyeong Jung ,  Hwan Mook Kim ,  Song Kyu Park ,  Ki Ho Lee ,  Chang Woo Lee ,  Joong-Kwon Choi ,  Jin Hee Ahn

IPC分类号： A61K31/426 ,  C07D277/04 ,  C07D413/12 ,  A61K31/538 ,  A61P3/10 ,  A61P35/00 ,  A61P3/04 ,  A61K31/5377 ,  C07D265/34

CPC分类号： C07D277/20 ,  C07D417/12

摘要： Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTP1B, Prl-3, LAR, CD45, Cdc25A, Cdc25B, Cdc25C, Yop, PP1 and VHR, and can be applied for the prevention and treatment of PPase-caused diseases, including autoimmune diseases, diabetes, impaired glucose intolerance, insulin resistance, obesity, cancers, etc. when the inhibitory activity thereof is modulated.

摘要翻译： 本文公开了绕丹宁衍生物，其制备方法和含有它们的药物组合物。 罗丹明衍生物对PTP1B，Prl-3，LAR，CD45，Cdc25A，Cdc25B，Cdc25C，Yop，PP1和VHR等蛋白磷酸酶（PPase）具有抑制活性，可用于预防和治疗PPase引起的疾病 包括自身免疫性疾病，糖尿病，葡萄糖耐受不良，胰岛素抵抗，肥胖，癌症等。

公开(公告)号：US20120220742A1

公开(公告)日：2012-08-30

申请号：US13394910

申请日：2010-05-11

申请人： Jin Ku Cho ,  Sang Yong Kim ,  Do Hoon Lee ,  Bo Ra Kim ,  Baek Jin Kim ,  Jae Won Jung ,  Sang Hyeup Lee ,  Jae Soung Lee

发明人： Jin Ku Cho ,  Sang Yong Kim ,  Do Hoon Lee ,  Bo Ra Kim ,  Baek Jin Kim ,  Jae Won Jung ,  Sang Hyeup Lee ,  Jae Soung Lee

IPC分类号： C08G65/22 ,  C07D407/14

CPC分类号： C07D407/14 ,  C08F2/48 ,  C08G59/26

摘要： The present invention relates to a furan-based curable compound derived from carbohydrate-based biomass, to a solvent-free curable composition, and to a method for preparing thereof, wherein the furan-based curable compound derived from biomass according to the present invention includes two epoxide functional groups bonded to at least one furan-based compound. The present invention may provide an environmentally friendly next-generation curable compound comprising a novel furan-based compound derived from biomass, which may be substituted for curable materials derived from oil resources, as a basic backbone, as well as a composition containing the same. According to the present invention, a curable material, which has a low contraction ratio during curing as compared to conventional radical-type curing materials, may be obtained, and a compound applied to the novel curing material may be prepared with a combination of excellent efficiency and cost-effectiveness.

摘要翻译： 本发明涉及一种衍生自碳水化合物的生物质的呋喃类固化性化合物，无溶剂的可固化组合物及其制备方法，其中衍生自本发明的生物质的呋喃类固化性化合物包括 两个与至少一种呋喃基化合物键合的环氧官能团。 本发明可以提供一种环保的下一代可固化化合物，其包含衍生自生物质的新型呋喃基化合物，其可以替代源自石油资源的可固化材料作为基本骨架，以及含有该衍生物的组合物。 根据本发明，可以获得与常规自由基固化材料相比在固化期间具有低收缩率的可固化材料，并且可以以优异的效率组合来制备应用于新型固化材料的化合物 和成本效益。