Method and arrangement for monitoring transport of hazardous materials includes arranging at least one sensor capable of detecting hazardous materials on a vehicle, transmitting information about the detection of hazardous materials by each sensor upon approach of the vehicle to infrastructure regulating the transport of the hazardous materials, and regulating the transit of the vehicle relative to the infrastructure based on whether any sensor provides information about the presence of hazardous materials on the vehicle. When the vehicles are trucks having trailers, each sensor can be arranged to detect hazardous materials in the trailer. When transit of hazardous materials through or over the infrastructure is prohibited, regulating the transit of the vehicle relative to the infrastructure may entail preventing the vehicle from passing through or over the infrastructure, e.g., by interposing a barrier to the vehicle's passage through or over the infrastructure.