发明申请
US20090069314A1 Hydroxyalkyl Substituted Imidazoquinoline Compounds and Methods
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羟烷基取代的咪唑并喹啉化合物和方法
- 专利标题: Hydroxyalkyl Substituted Imidazoquinoline Compounds and Methods
- 专利标题(中): 羟烷基取代的咪唑并喹啉化合物和方法
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申请号: US11885006申请日: 2006-02-22
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公开(公告)号: US20090069314A1公开(公告)日: 2009-03-12
- 发明人: Tushar A. Kshirsagar , Bryon A. Merrill , Shri Niwas , Gregory D. Lundquist, JR. , Philip D. Heppner , Michael E. Danielson
- 申请人: Tushar A. Kshirsagar , Bryon A. Merrill , Shri Niwas , Gregory D. Lundquist, JR. , Philip D. Heppner , Michael E. Danielson
- 申请人地址: US MA Wellesley
- 专利权人: Coley Pharmaceutical Group, Inc.
- 当前专利权人: Coley Pharmaceutical Group, Inc.
- 当前专利权人地址: US MA Wellesley
- 国际申请: PCT/US06/06042 WO 20060222
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; C07D471/04 ; A61K31/437 ; A61K31/496 ; A61P31/12 ; A61P35/00 ; C07D401/14 ; C07D413/14
摘要:
Certain imidazoquinolines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, and an aryl or heteroaryl substituent at the 7-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-α biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
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