发明申请
- 专利标题: Supramolecular Functionalization of Graphitic Nanoparticles for Drug Delivery
- 专利标题(中): 石墨纳米粒子用于药物递送的超分子官能化
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申请号: US12178891申请日: 2008-07-24
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公开(公告)号: US20090087493A1公开(公告)日: 2009-04-02
- 发明人: Hongjie Dai , Zhuang Liu , Xiaolin Li , Xiaoming Sun
- 申请人: Hongjie Dai , Zhuang Liu , Xiaolin Li , Xiaoming Sun
- 申请人地址: US CA Palo Alto
- 专利权人: The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人: The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人地址: US CA Palo Alto
- 主分类号: A61K9/16
- IPC分类号: A61K9/16 ; C12N5/00 ; A61K39/395
摘要:
Disclosed are nanoparticles, such as carbon nanotubes or other materials having extended aromatic surfaces (e.g., graphene sheet or nanotube), which are used to deliver active agents such as drugs, labels or dyes (termed for convenience a “drug”) to the interior of cells. The nanoparticles are functionalized by a hydrophilic polymer to render them stable in suspension. This molecule may be covalently attached to the nanoparticle, or may be adsorbed thereto as an amphiphilic molecule. The nanoparticles are coupled to the drug through supramolecular bonding i.e., binding to the exterior of the nanoparticle through π-stacking. The drug may also be covalently bonded to the hydrophilic polymer, which is coupled to the nanoparticle through supramolecular bonding. The drug is therefore capable of release in the cell exterior. The drug is more rapidly released at lower pH, as found e.g., in tumor cells. The drug-coupled, functionalized nanoparticles may also be targeted to specific cells through modification of the hydrophilic polymer, e.g., by adding an RGD peptide, or an antibody, which is targeted to cells expressing integrins, or an antibody directed to a cell surface marker. The drug may also be linked to a branched chain hydrophilic polymer, so that each polymer molecule carries more than one drug bound by a cleavable linker.