发明申请
US20090099072A1 Motif of the Beclin Protein Which Interacts with Anti-Apoptotic Members of the Bcl-2 Protein Family, and Uses
失效
与Bcl-2蛋白家族的抗凋亡成员相互作用的Beclin蛋白的主题及其用途
- 专利标题： Motif of the Beclin Protein Which Interacts with Anti-Apoptotic Members of the Bcl-2 Protein Family, and Uses
- 专利标题（中）： 与Bcl-2蛋白家族的抗凋亡成员相互作用的Beclin蛋白的主题及其用途
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申请号： US11883438申请日： 2006-01-31
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公开(公告)号： US20090099072A1公开(公告)日： 2009-04-16
- 发明人: Olivier Geneste , John Hickman , Jean-Christophe Rain
- 申请人： Olivier Geneste , John Hickman , Jean-Christophe Rain
- 国际申请： PCT/FR06/00205 WO 20060131
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C12Q1/00 ; C07K16/00 ; C07H21/04 ; C12N15/00 ; C12N1/34
摘要：
The invention relates to a method of identifying modulators of programmed cell death, comprising an interaction between a motif of Beclin protein and an anti-apoptotic member of the family of Bcl-2 proteins and the detection of said interaction be means of fluorescence polarisation. The modulators identified on the basis of said method are administered to cancer patients in order to induce apoptotic- and/or autophagic-type programmed cell death. The invention also relates to a motif of the Beclin protein which can interact with an anti-apoptic member of the family of Bcl-2 proteins and to the use thereof in order to induce programmed cell death in a cancer patient.
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