发明申请
- 专利标题： INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1
- 专利标题（中）： 11-羟基脱氢酶脱氢酶抑制剂1
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申请号： US12297964申请日： 2007-04-24
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公开(公告)号： US20090099182A1公开(公告)日： 2009-04-16
- 发明人: Renhua Li , Thomas Edward Mabry , Owen Brendan Wallace , Leonard Larry Winneroski, JR. , Yanping Xu
- 申请人： Renhua Li , Thomas Edward Mabry , Owen Brendan Wallace , Leonard Larry Winneroski, JR. , Yanping Xu
- 国际申请： PCT/US07/67296 WO 20070424
- 主分类号： A61K31/4015
- IPC分类号： A61K31/4015 ; C07D207/27 ; C07D403/10 ; C07D413/10 ; C07D401/10 ; C07D401/04 ; A61K31/5377 ; C07D401/14 ; A61K31/496 ; A61K31/454 ; A61K31/4545 ; A61P3/10
摘要：
The present invention discloses novel compounds of Formula I: having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity.
公开/授权文献
- US07994176B2 Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 公开/授权日：2011-08-09
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