发明申请
- 专利标题： Methods for Determining Probability of an Adverse or Favorable Reaction to a Niacin Receptor Agonist
- 专利标题（中）： 确定烟酸受体激动剂不利或有利反应概率的方法
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申请号： US11990240申请日： 2006-08-09
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公开(公告)号： US20090117559A1公开(公告)日： 2009-05-07
- 发明人: Chen W. Liaw , Martha Kanemitsu-Parks , Jeremy G. Richman , Dominique Maciejewski-Lenoir , Daniel T. Connolly
- 申请人： Chen W. Liaw , Martha Kanemitsu-Parks , Jeremy G. Richman , Dominique Maciejewski-Lenoir , Daniel T. Connolly
- 国际申请： PCT/US2006/031032 WO 20060809
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
The present invention relates generally to a GPR109A niacin receptor. The present invention relates more particularly to assessing a GPR109A polymorphism in an individual, wherein the GPR109A polymorphism is indicative of the subject's risk for an adverse reaction to the administration of a GPR109A receptor agonist, wherein the adverse reaction is associated with stimulation of MAP kinase activity by the GPR109A receptor agonist. More specifically, the present invention relates to assessing a GPR109A polymorphism in an individual and determining the level of risk for the subject for experiencing an adverse reaction, wherein the subject's GPR109A zygosity is predictive of the risk for a cutaneous flushing response that can be experienced following administration of a GPR109A receptor agonist.
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