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    Compositions For Treating Flushing And Lipid-Associated Disorders Comprising Niacin Receptor Partial Agonists
    2.
    发明申请
    Compositions For Treating Flushing And Lipid-Associated Disorders Comprising Niacin Receptor Partial Agonists 审中-公开
    用于治疗包含烟酸受体部分激动剂的潮红和脂质相关疾病的组合物

    公开(公告)号：US20080139628A1

    公开(公告)日：2008-06-12

    申请号：US11718539

    申请日：2005-11-01

    申请人： Dominic P. Behan ,  Daniel T. Connolly ,  Jeremy G. Richman

    发明人： Dominic P. Behan ,  Daniel T. Connolly ,  Jeremy G. Richman

    IPC分类号： A61K31/4406 ,  C07D403/04 ,  A61K31/41 ,  A61P3/00 ,  C07D231/14 ,  A61K31/415

    CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4162 ,  A61K31/455 ,  A61K2300/00

    摘要： The invention provides a method of reducing flushing induced by niacin or a niacin analog in a subject, comprising administering to said subject an effective flush reducing amount of a niacin receptor partial agonist. In addition, the invention provides a method of reducing flushing induced by niacin or a niacin analog in a subject, comprising administering to said subject an effective flush reducing amount of a niacin receptor partial agonist and an effective lipid altering amount of niacin or a niacin analog. The invention further provides a method of reducing flushing induced by niacin or a niacin analog in a subject, comprising administering to said subject an effective flush reducing amount of a niacin receptor partial agonist and subsequently administering to said subject an effective lipid altering amount of niacin or a niacin analog.

    摘要翻译： 本发明提供了一种减少受试者中烟酸或烟酸类似物引起的潮红的方法，包括向所述受试者施用有效冲洗减少量的烟酸受体部分激动剂。 此外，本发明提供了一种减少受试者中烟酸或烟酸类似物引起的潮红的方法，包括向所述受试者施用有效冲洗减少量的烟酸受体部分激动剂和有效的脂质改变量的烟酸或烟酸类似物 。 本发明进一步提供了一种减少受试者中烟酸或烟酸类似物引起的潮红的方法，包括向所述受试者施用有效冲洗减少量的烟酸受体部分激动剂，随后向所述受试者施用有效的脂质改变量的烟酸或 烟酸类似物。

    Methods for Determining Probability of an Adverse or Favorable Reaction to a Niacin Receptor Agonist
    4.
    发明申请
    Methods for Determining Probability of an Adverse or Favorable Reaction to a Niacin Receptor Agonist 审中-公开
    确定烟酸受体激动剂不利或有利反应概率的方法

    公开(公告)号：US20090117559A1

    公开(公告)日：2009-05-07

    申请号：US11990240

    申请日：2006-08-09

    申请人： Chen W. Liaw ,  Martha Kanemitsu-Parks ,  Jeremy G. Richman ,  Dominique Maciejewski-Lenoir ,  Daniel T. Connolly

    发明人： Chen W. Liaw ,  Martha Kanemitsu-Parks ,  Jeremy G. Richman ,  Dominique Maciejewski-Lenoir ,  Daniel T. Connolly

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： The present invention relates generally to a GPR109A niacin receptor. The present invention relates more particularly to assessing a GPR109A polymorphism in an individual, wherein the GPR109A polymorphism is indicative of the subject's risk for an adverse reaction to the administration of a GPR109A receptor agonist, wherein the adverse reaction is associated with stimulation of MAP kinase activity by the GPR109A receptor agonist. More specifically, the present invention relates to assessing a GPR109A polymorphism in an individual and determining the level of risk for the subject for experiencing an adverse reaction, wherein the subject's GPR109A zygosity is predictive of the risk for a cutaneous flushing response that can be experienced following administration of a GPR109A receptor agonist.

    摘要翻译： 本发明一般涉及一种GPR109A烟酸受体。 本发明更具体地涉及评估个体中的GPR109A多态性，其中GPR109A多态性指示受试者对施用GPR109A受体激动剂的不良反应的风险，其中不良反应与MAP激酶活性的刺激相关 由GPR109A受体激动剂。 更具体地，本发明涉及评估个体中的GPR109A多态性并确定受试者经历不良反应的风险水平，其中受试者的GPR109A接合度预示出可能经历的皮肤潮红反应的风险 给予GPR109A受体激动剂。