公开(公告)号：US20090117559A1

公开(公告)日：2009-05-07

申请号：US11990240

申请日：2006-08-09

申请人： Chen W. Liaw ,  Martha Kanemitsu-Parks ,  Jeremy G. Richman ,  Dominique Maciejewski-Lenoir ,  Daniel T. Connolly

发明人： Chen W. Liaw ,  Martha Kanemitsu-Parks ,  Jeremy G. Richman ,  Dominique Maciejewski-Lenoir ,  Daniel T. Connolly

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present invention relates generally to a GPR109A niacin receptor. The present invention relates more particularly to assessing a GPR109A polymorphism in an individual, wherein the GPR109A polymorphism is indicative of the subject's risk for an adverse reaction to the administration of a GPR109A receptor agonist, wherein the adverse reaction is associated with stimulation of MAP kinase activity by the GPR109A receptor agonist. More specifically, the present invention relates to assessing a GPR109A polymorphism in an individual and determining the level of risk for the subject for experiencing an adverse reaction, wherein the subject's GPR109A zygosity is predictive of the risk for a cutaneous flushing response that can be experienced following administration of a GPR109A receptor agonist.

摘要翻译： 本发明一般涉及一种GPR109A烟酸受体。 本发明更具体地涉及评估个体中的GPR109A多态性，其中GPR109A多态性指示受试者对施用GPR109A受体激动剂的不良反应的风险，其中不良反应与MAP激酶活性的刺激相关 由GPR109A受体激动剂。 更具体地，本发明涉及评估个体中的GPR109A多态性并确定受试者经历不良反应的风险水平，其中受试者的GPR109A接合度预示出可能经历的皮肤潮红反应的风险 给予GPR109A受体激动剂。

公开(公告)号：US20080161422A1

公开(公告)日：2008-07-03

申请号：US11884675

申请日：2006-02-18

申请人： Martha Kanemitsu-Parks ,  Jeremy G. Richman ,  Dominique Maciejewski-Lenoir ,  Daniel T. Connolly

发明人： Martha Kanemitsu-Parks ,  Jeremy G. Richman ,  Dominique Maciejewski-Lenoir ,  Daniel T. Connolly

IPC分类号： A61K35/00 ,  C12Q1/48 ,  G01N33/566

CPC分类号： G01N33/566 ,  G01N2333/9121 ,  G01N2500/04

摘要： The invention provides a method of identifying a niacin receptor modulator with reduced flushing effect compared to niacin or a niacin analog, comprising determining the MAP kinase activity of said modulator, wherein a decrease in MAP kinase activity induced by said modulator compared to MAP kinase activity induced by niacin or a niacin analog indicates that said modulator has reduced flushing effect when compared to niacin or a niacin analog.

摘要翻译： 本发明提供了一种鉴定与烟酸或烟酸类似物相比具有降低的冲洗作用的烟酸受体调节剂的方法，其包括确定所述调节剂的MAP激酶活性，其中所述调节剂诱导的MAP激酶活性与MAP诱导的诱导相比有降低 由烟酸或烟酸类似物表明，与烟酸或烟酸类似物相比，所述调节剂具有降低的冲洗效果。