发明申请
- 专利标题: BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE
- 专利标题(中): 苯甲酰基吡咯烷酮衍生物
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申请号: US12280510申请日: 2007-08-03
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公开(公告)号: US20090137499A1公开(公告)日: 2009-05-28
- 发明人: Takeshi Honda , Minoru Oguchi , Masao Yoshida , Ryo Okuyama , Tsuneaki Ogata , Manabu Abe , Kenjiro Ueda , Jun Ohsumi , Masanori Izumi
- 申请人: Takeshi Honda , Minoru Oguchi , Masao Yoshida , Ryo Okuyama , Tsuneaki Ogata , Manabu Abe , Kenjiro Ueda , Jun Ohsumi , Masanori Izumi
- 优先权: JP2006-213600 20060804
- 国际申请: PCT/JP2007/065231 WO 20070803
- 主分类号: A61K31/706
- IPC分类号: A61K31/706 ; C07G3/00 ; A61K31/7004 ; C07H17/02
摘要:
The present invention relates to a benzylphenyl glucopyranoside derivative having an excellent inhibitory effect on human SGLT1 and/or SGLT2 activity. There is provided a compound or a pharmacologically acceptable salt thereof represented by the following general formula (I): wherein R1 represents a hydrogen atom, an amino group, a hydroxy C1-C6 alkyl group, etc.; R2 represents a hydrogen atom, etc.; R3 represents a C1-C6 alkyl group, a hydroxy C1-C6 alkyl group, etc.; R4 represents a hydrogen atom, a C2-C7 acyl group, etc.; R5, R6, R7, and R8 are the same or different and each represents a hydrogen atom or a C1-C6 alkyl group, provided that R5, R6, R7 and R8 are not hydrogen atoms at the same time; n is 0 to 4; and X is CH or N.
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