公开(公告)号：US20090137499A1

公开(公告)日：2009-05-28

申请号：US12280510

申请日：2007-08-03

申请人： Takeshi Honda ,  Minoru Oguchi ,  Masao Yoshida ,  Ryo Okuyama ,  Tsuneaki Ogata ,  Manabu Abe ,  Kenjiro Ueda ,  Jun Ohsumi ,  Masanori Izumi

发明人： Takeshi Honda ,  Minoru Oguchi ,  Masao Yoshida ,  Ryo Okuyama ,  Tsuneaki Ogata ,  Manabu Abe ,  Kenjiro Ueda ,  Jun Ohsumi ,  Masanori Izumi

IPC分类号： A61K31/706 ,  C07G3/00 ,  A61K31/7004 ,  C07H17/02

CPC分类号： C07H15/203 ,  A61K9/2018 ,  C07H17/02

摘要： The present invention relates to a benzylphenyl glucopyranoside derivative having an excellent inhibitory effect on human SGLT1 and/or SGLT2 activity. There is provided a compound or a pharmacologically acceptable salt thereof represented by the following general formula (I): wherein R1 represents a hydrogen atom, an amino group, a hydroxy C1-C6 alkyl group, etc.; R2 represents a hydrogen atom, etc.; R3 represents a C1-C6 alkyl group, a hydroxy C1-C6 alkyl group, etc.; R4 represents a hydrogen atom, a C2-C7 acyl group, etc.; R5, R6, R7, and R8 are the same or different and each represents a hydrogen atom or a C1-C6 alkyl group, provided that R5, R6, R7 and R8 are not hydrogen atoms at the same time; n is 0 to 4; and X is CH or N.

摘要翻译： 本发明涉及对人SGLT1和/或SGLT2活性具有优异抑制作用的苄基苯基吡喃葡萄糖苷衍生物。 提供由以下通式（I）表示的化合物或其药理学上可接受的盐：其中R1表示氢原子，氨基，羟基C1-C6烷基等; R2表示氢原子等; R3表示C1-C6烷基，羟基C1-C6烷基等; R4表示氢原子，C2-C7酰基等; R5，R6，R7和R8相同或不同，各自表示氢原子或C1-C6烷基，条件是R5，R6，R7和R8不同时为氢原子; n为0〜4; X为CH或N.