发明申请
US20090142263A1 Cytotoxicity mediation of cells evidencing surface expression of TROP-2
审中-公开
证实TROP-2表面表达的细胞的细胞毒性调解
- 专利标题： Cytotoxicity mediation of cells evidencing surface expression of TROP-2
- 专利标题（中）： 证实TROP-2表面表达的细胞的细胞毒性调解
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申请号： US12229187申请日： 2008-08-20
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公开(公告)号： US20090142263A1公开(公告)日： 2009-06-04
- 发明人: David S. F. Young , Helen P. Findlay , Susan E. Hahn , Luis A. G. DaCruz , Alison L. Ferry
- 申请人： David S. F. Young , Helen P. Findlay , Susan E. Hahn , Luis A. G. DaCruz , Alison L. Ferry
- 专利权人： Arius Research Inc.
- 当前专利权人： Arius Research Inc.
- 主分类号： A61K51/10
- IPC分类号： A61K51/10 ; C07K16/00 ; A01N1/02 ; G01N33/574 ; A61K39/395
摘要：
The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells.
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