公开(公告)号：US07452978B2

公开(公告)日：2008-11-18

申请号：US11496390

申请日：2006-07-31

申请人： David S. F. Young ,  Susan E. Hahn ,  Lisa M. Cechetto

发明人： David S. F. Young ,  Susan E. Hahn ,  Lisa M. Cechetto

IPC分类号： C07K16/00 ,  C12P21/08 ,  A61K39/00 ,  G01N33/53 ,  A61K39/395

CPC分类号： G01N33/57492 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/73 ,  G01N33/57488

摘要： The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

公开(公告)号：US20080267864A1

公开(公告)日：2008-10-30

申请号：US12217148

申请日：2008-07-01

申请人： David S.F. Young ,  Helen P. Findlay ,  Susan E. Hahn ,  Lisa M. Cechetto ,  Fortunata McConkey ,  Daad Sayegh

发明人： David S.F. Young ,  Helen P. Findlay ,  Susan E. Hahn ,  Lisa M. Cechetto ,  Fortunata McConkey ,  Daad Sayegh

IPC分类号： A61K51/10 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K16/30 ,  A61K38/21 ,  A61K47/6851 ,  A61K51/1045 ,  A61K2039/505

摘要： The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells.

公开(公告)号：US07361343B2

公开(公告)日：2008-04-22

申请号：US10810751

申请日：2004-03-26

申请人： David S. F. Young ,  Susan E. Hahn ,  Helen P. Findlay ,  Luis A. G. da Cruz

发明人： David S. F. Young ,  Susan E. Hahn ,  Helen P. Findlay ,  Luis A. G. da Cruz

IPC分类号： A61K39/395 ,  A61K39/00 ,  C07K16/00 ,  C12P21/08

CPC分类号： A61K51/1045 ,  A61K47/6851 ,  A61K51/1051 ,  A61K51/1096 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3069 ,  C07K16/3076 ,  G01N33/57484 ,  G01N33/57492

摘要： This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays which utilize the CDMABs of the instant invention.

公开(公告)号：US20080025977A1

公开(公告)日：2008-01-31

申请号：US11807681

申请日：2007-05-30

申请人： David Young ,  Helen Findlay ,  Susan Hahn ,  Lisa Cechetto ,  Luis de Cruz

发明人： David Young ,  Helen Findlay ,  Susan Hahn ,  Lisa Cechetto ,  Luis de Cruz

IPC分类号： A61K39/395 ,  A61P43/00 ,  C07K16/18 ,  G01N33/53

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/734 ,  G01N33/57492 ,  G01N2333/70596

摘要： This invention relates to the staging, diagnosis and treatment of cancerous diseases (both primary tumors and tumor metastases), particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more CDMAB/chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays, which utilize the CDMAB of the instant invention. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells.

摘要翻译： 本发明涉及癌性疾病（原发性肿瘤和肿瘤转移）的分期，诊断和治疗，特别是涉及肿瘤细胞的细胞毒性的介导; 并且最特别地涉及可选地与一种或多种CDMAB /化学治疗剂组合使用癌性疾病修饰抗体（CDMAB）作为起始细胞毒性应答的手段。 本发明还涉及利用本发明的CDMAB的结合测定法。 抗癌抗体可以与毒素，酶，放射性化合物，细胞因子，干扰素，靶或报告物部分和血细胞结合。

公开(公告)号：US07256271B2

公开(公告)日：2007-08-14

申请号：US10348284

申请日：2003-01-21

申请人： David S. F. Young ,  Susan E. Hahn

发明人： David S. F. Young ,  Susan E. Hahn

IPC分类号： C07K16/00 ,  C12P21/08 ,  A61K39/395 ,  A61K39/00

CPC分类号： C07K16/30 ,  G01N33/574

摘要： The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

公开(公告)号：US20060140963A1

公开(公告)日：2006-06-29

申请号：US11361153

申请日：2006-02-24

申请人： David Young ,  Helen Findlay ,  Susan Hahn ,  Lisa Cechetto ,  Luis da Cruz

发明人： David Young ,  Helen Findlay ,  Susan Hahn ,  Lisa Cechetto ,  Luis da Cruz

IPC分类号： G01N33/574 ,  A61K39/395 ,  C07K16/30

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/303 ,  C07K2317/24 ,  G01N33/57492 ,  G01N2333/70596

摘要： This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays which utilize the CDMAB of the instant invention.

公开(公告)号：US20050002940A1

公开(公告)日：2005-01-06

申请号：US10891866

申请日：2004-07-15

申请人： David Young ,  Susan Hahn ,  Helen Findlay

发明人： David Young ,  Susan Hahn ,  Helen Findlay

IPC分类号： A61K51/10 ,  A61P35/00 ,  C07K16/00 ,  C07K16/30 ,  C12N5/18 ,  G01N33/574 ,  C12Q1/68 ,  A61K39/395

CPC分类号： C07K16/3046 ,  A61K51/1045 ,  A61K51/1051 ,  A61K51/1096 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3069 ,  G01N33/574 ,  G01N33/57484

摘要： The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

公开(公告)号：US20040141979A1

公开(公告)日：2004-07-22

申请号：US10743451

申请日：2003-12-19

申请人： Arius Research, Inc.

发明人： David S.F. Young ,  Susan E. Hahn ,  Helen P. Findlay

IPC分类号： A61K051/00 ,  A61K039/395

CPC分类号： C07K16/3046 ,  A61K51/1045 ,  A61K51/1051 ,  A61K51/1096 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3069 ,  G01N33/574 ,  G01N33/57484

摘要： The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

公开(公告)号：US20100166652A1

公开(公告)日：2010-07-01

申请号：US12217191

申请日：2008-07-01

申请人： David S. F. Young ,  Susan E. Hahn ,  Fortunata McConkey ,  Michelle Kelleher ,  Andrea Warner

发明人： David S. F. Young ,  Susan E. Hahn ,  Fortunata McConkey ,  Michelle Kelleher ,  Andrea Warner

IPC分类号： A61K51/10 ,  C12N5/071 ,  G01N33/567 ,  A61K39/395 ,  A61K49/00 ,  A61P35/00

CPC分类号： C07K16/303 ,  A61K47/6851 ,  C07K16/30 ,  C07K16/3069 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57438 ,  G01N33/57449 ,  G01N33/57476 ,  G01N33/6893

摘要： This invention relates to the diagnosis and treatment of cancerous diseases, particularly to such diagnosis and treatment which revolves around the ability of the 5LAC-23 monoclonal antibody (or antigenic binding fragments derived therefrom) to bind with the Laminin Receptor 1 Precursor Protein 37LRP; and most particularly to diagnosis and treatment of Hepatocellular Carcinoma by various means which rely upon direct binding of 5LAC-23 with the particular antigenic moiety specifically recognized thereby and generally overexpressed in Hepatocellular carcinoma cells. The invention additionally relates to the treatment of such cells with conjugated moieties effective to aid in differentiation, treatment and diagnostic imaging thereof.

摘要翻译： 本发明涉及癌细胞疾病的诊断和治疗，特别涉及以5LAC-23单克隆抗体（或其衍生自其衍生的抗原结合片段）与层粘连蛋白受体1前体蛋白37LRP结合的能力的诊断和治疗; 最特别的是通过各种手段诊断和治疗肝细胞癌，这些方法依赖于5LAC-23与由此特异性识别的特定抗原部分的直接结合，并且通常在肝细胞癌细胞中过表达。 本发明还涉及这种具有有助于分化，治疗和诊断成像的共轭部分的细胞的治疗。

公开(公告)号：US20090022722A1

公开(公告)日：2009-01-22

申请号：US12220362

申请日：2008-07-23

申请人： David S.F. Young ,  Helen P. Findlay ,  Susan E. Hahn ,  Lisa M. Cechetto ,  Luis A.G. da Cruz

发明人： David S.F. Young ,  Helen P. Findlay ,  Susan E. Hahn ,  Lisa M. Cechetto ,  Luis A.G. da Cruz

IPC分类号： A61K39/395 ,  C07K16/00 ,  G01N33/574

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/303 ,  C07K2317/24 ,  G01N33/57492 ,  G01N2333/70596

摘要： This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays which utilize the CDMAB of the instant invention.

摘要翻译： 本发明涉及癌症的诊断和治疗，特别涉及肿瘤细胞的细胞毒性的介导; 并且最特别地涉及使用任选与一种或多种化学治疗剂组合的癌性疾病修饰抗体（CDMAB）作为起始细胞毒性应答的手段。 本发明还涉及利用本发明的CDMAB的结合测定法。