发明申请
- 专利标题： Human adam-10 inhibitors
- 专利标题（中）： 人类adam-10抑制剂
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申请号： US12322422申请日： 2009-02-02
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公开(公告)号： US20090143386A1公开(公告)日： 2009-06-04
- 发明人: S. David Brown , Lynne Canne-Bannen , Erick Wang Co , Vasu Jammalamadaka , Rickard George Khoury , Moon Hwan Kim , Donna T. Le , Amy Lew Tsuhako , Morrison B. Mac , Shumeye Mamo , John M. Nuss , Michael P. Prisbylla , Wei Xu
- 申请人： S. David Brown , Lynne Canne-Bannen , Erick Wang Co , Vasu Jammalamadaka , Rickard George Khoury , Moon Hwan Kim , Donna T. Le , Amy Lew Tsuhako , Morrison B. Mac , Shumeye Mamo , John M. Nuss , Michael P. Prisbylla , Wei Xu
- 主分类号： A61K31/5375
- IPC分类号： A61K31/5375 ; C07C311/00 ; A61K31/215 ; A61K31/445 ; A61K31/4965 ; C07D241/04 ; C07D211/30 ; C07D295/00
摘要：
The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chlorides and ADAM-10 modulators therefrom.
公开/授权文献
- US07951972B2 Human adam-10 inhibitors 公开/授权日：2011-05-31
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