Invention Application
- Patent Title: Human adam-10 inhibitors
- Patent Title (中): 人类adam-10抑制剂
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Application No.: US12322422Application Date: 2009-02-02
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Publication No.: US20090143386A1Publication Date: 2009-06-04
- Inventor: S. David Brown , Lynne Canne-Bannen , Erick Wang Co , Vasu Jammalamadaka , Rickard George Khoury , Moon Hwan Kim , Donna T. Le , Amy Lew Tsuhako , Morrison B. Mac , Shumeye Mamo , John M. Nuss , Michael P. Prisbylla , Wei Xu
- Applicant: S. David Brown , Lynne Canne-Bannen , Erick Wang Co , Vasu Jammalamadaka , Rickard George Khoury , Moon Hwan Kim , Donna T. Le , Amy Lew Tsuhako , Morrison B. Mac , Shumeye Mamo , John M. Nuss , Michael P. Prisbylla , Wei Xu
- Main IPC: A61K31/5375
- IPC: A61K31/5375 ; C07C311/00 ; A61K31/215 ; A61K31/445 ; A61K31/4965 ; C07D241/04 ; C07D211/30 ; C07D295/00
Abstract:
The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chlorides and ADAM-10 modulators therefrom.
Public/Granted literature
- US07951972B2 Human adam-10 inhibitors Public/Granted day:2011-05-31
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