![[4-(6-FLUORO-7-METHYLAMINO-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREA SALTS, FORMS AND METHODS RELATED THERETO](/docs/US/2009-06-18/US20090156620A1/abs.jpg.600x600.jpg)
- 专利标题： [4-(6-FLUORO-7-METHYLAMINO-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREA SALTS, FORMS AND METHODS RELATED THERETO
-
申请号： US12265699申请日： 2008-11-05
-
公开(公告)号： US20090156620A1公开(公告)日： 2009-06-18
- 发明人: Emma Sharp , Louisa Jane Quegan , Anjali Pandey , Juan Wang , Matthew Nieder , Wolin Huang
- 申请人： Emma Sharp , Louisa Jane Quegan , Anjali Pandey , Juan Wang , Matthew Nieder , Wolin Huang
- 申请人地址： US CA South San Francisco
- 专利权人： Portola Pharmaceuticals, Inc.
- 当前专利权人： Portola Pharmaceuticals, Inc.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： C07D409/12
- IPC分类号： C07D409/12 ; A61K31/517 ; C12N5/06 ; A61P9/00 ; A61P7/00
![[4-(6-FLUORO-7-METHYLAMINO-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREA SALTS, FORMS AND METHODS RELATED THERETO](/abs-image/US/2009/06/18/US20090156620A1/abs.jpg.150x150.jpg)
摘要：
The present invention provides novel sulfonylurea salts of a salt of formula (I) and polymorph forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a salt of formula (I) or a pharmaceutically acceptable form thereof.
信息查询
