利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

45 条记录 (耗时 0.043 秒)

    [4-(6-FLUORO-7-METHYLAMINO-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREA SALTS, FORMS AND METHODS RELATED THERETO
    1.
    发明申请
    [4-(6-FLUORO-7-METHYLAMINO-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREA SALTS, FORMS AND METHODS RELATED THERETO 审中-公开
    [4-（6-氟代-7-甲基氨基-2,4-二氧代-1,4-二氢-2H-喹喔啉-3-基） - 苯基] -5-氯代噻二氢-2-甲磺酰胺盐，形式 及其相关方法

    公开(公告)号：US20120129876A1

    公开(公告)日：2012-05-24

    申请号：US13166763

    申请日：2011-06-22

    申请人： Emma Sharp ,  Louisa Jane Quegan ,  Anjali Pandey ,  Juan Wang ,  Matthew Nieder ,  Wolin Huang

    发明人： Emma Sharp ,  Louisa Jane Quegan ,  Anjali Pandey ,  Juan Wang ,  Matthew Nieder ,  Wolin Huang

    IPC分类号： A61K31/517 ,  A61P9/10 ,  A61P7/02 ,  C07D409/12 ,  A01N1/02

    CPC分类号： C07D409/12

    摘要： The present invention provides novel sulfonylurea salts of a salt of formula (I) and polymorph forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a salt of formula (I) or a pharmaceutically acceptable form thereof.

    摘要翻译： 本发明提供式（I）的盐的新型磺酰脲盐及其多晶型形式。 各种形式的化合物是有效的血小板ADP受体抑制剂，可用于各种药物组合物中，并且特别有效预防和/或治疗心血管疾病，特别是与血栓形成有关的疾病。 本发明还提供了一种制备此类化合物和形式并用于预防或治疗哺乳动物血栓形成和血栓形成相关病症的方法，包括施用治疗有效量的式（I）的盐或其药学上可接受的形式的步骤。

    [4-(6-FLUORO-7-METHYLAMINO-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREA SALTS, FORMS AND METHODS RELATED THERETO
    2.
    发明申请
    [4-(6-FLUORO-7-METHYLAMINO-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREA SALTS, FORMS AND METHODS RELATED THERETO 审中-公开
    [4-（6-氟代-7-甲基氨基-2,4-二氧代-1,4-二氢-2H-喹喔啉-3-基） - 苯基] -5-氯代噻二氢-2-甲磺酰胺盐，形式 及其相关方法

    公开(公告)号：US20090042916A1

    公开(公告)日：2009-02-12

    申请号：US12114742

    申请日：2008-05-02

    申请人： Emma Sharp ,  Louisa Jane Quegan ,  Anjali Pandey ,  Juan Wang ,  Matthew Nieder ,  Wolin Huang

    发明人： Emma Sharp ,  Louisa Jane Quegan ,  Anjali Pandey ,  Juan Wang ,  Matthew Nieder ,  Wolin Huang

    IPC分类号： A61K31/517 ,  C07D405/12 ,  A61P7/02 ,  A61P9/10

    CPC分类号： C07D409/12

    摘要： The present invention provides novel sulfonylurea salts of a salt of formula (I) and polymorph forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a salt of formula (I) or a pharmaceutically acceptable form thereof.

    摘要翻译： 本发明提供式（I）的盐的新型磺酰脲盐及其多晶型形式。 各种形式的化合物是有效的血小板ADP受体抑制剂，可用于各种药物组合物中，并且特别有效预防和/或治疗心血管疾病，特别是与血栓形成有关的疾病。 本发明还提供了一种制备此类化合物和形式并用于预防或治疗哺乳动物血栓形成和血栓形成相关病症的方法，包括施用治疗有效量的式（I）的盐或其药学上可接受的形式的步骤。

    OXYPYRIMIDINES AS SYK MODULATORS
    9.
    发明申请
    OXYPYRIMIDINES AS SYK MODULATORS 审中-公开
    氧化亚胺作为SYK调节剂

    公开(公告)号：US20130317029A1

    公开(公告)日：2013-11-28

    申请号：US13882958

    申请日：2011-11-01

    申请人： Anjali Pandey ,  Qing Xu ,  Wolin Huang ,  Zhaozhong J. Jia ,  Yonghong Song

    发明人： Anjali Pandey ,  Qing Xu ,  Wolin Huang ,  Zhaozhong J. Jia ,  Yonghong Song

    IPC分类号： C07D239/48 ,  C07D405/12 ,  C07D417/12 ,  C07D403/12 ,  C07D401/12

    CPC分类号： C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

    摘要： The present invention is directed to compounds of formula (I) and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which arc inhibitor of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.

    摘要翻译： 本发明涉及其抑制Syk激酶的式（I）化合物及其互变异构体或其药学上可接受的盐，酯和前药。 本发明还涉及用于制备这些化合物的中间体，这种化合物的制备，含有这种化合物的药物组合物，抑制Syk激酶活性的方法，抑制血小板聚集的方法，以及预防或治疗数字的方法 至少部分地由Syk激酶活性介导的病症，例如不期望的血栓形成和非霍奇金淋巴瘤。