发明申请
US20090209748A1 OLIGONUCLEOTIDES WITH ALTERNATING SEGMENTS OF LOCKED AND NON-LOCKED NUCLEOTIDES
有权
具有锁定和非锁定核心的替代部分的寡核苷酸
- 专利标题： OLIGONUCLEOTIDES WITH ALTERNATING SEGMENTS OF LOCKED AND NON-LOCKED NUCLEOTIDES
- 专利标题（中）： 具有锁定和非锁定核心的替代部分的寡核苷酸
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申请号： US10717434申请日： 2003-11-18
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公开(公告)号： US20090209748A1公开(公告)日： 2009-08-20
- 发明人: Charlotte Albaek Thrue , Christoph Rosenbohm , Henrik Frydenlund Hansen , Majken Westergaard , Nikolaj Dam Mikkelsen , Signe Christensen , Troels Koch , Daniel Sejer Pedersen , Miriam Frieden
- 申请人： Charlotte Albaek Thrue , Christoph Rosenbohm , Henrik Frydenlund Hansen , Majken Westergaard , Nikolaj Dam Mikkelsen , Signe Christensen , Troels Koch , Daniel Sejer Pedersen , Miriam Frieden
- 专利权人： Santaris Pharma A/S
- 当前专利权人： Santaris Pharma A/S
- 优先权： DKPA200301540 20031020
- 主分类号： C07H21/00
- IPC分类号： C07H21/00
摘要：
The present invention is directed to novel oligonucleotides with improved antisense properties. The novel oligonucleotides comprise at least one Locked Nucleic Acid (LNA) selected from beta-D-thio/amino-LNA or alpha-L-oxy/thio/amino-LNA. The oligonucleotides comprising LNA may also include DNA and/or RNA nucleotides. The present invention also provides a new class of pharmaceuticals which comprise antisense oligonucleotides and are useful in antisense therapy.