发明申请
US20090226471A1 METHODS OF MHC CLASS II EPITOPE MAPPING, DETECTION OF AUTOIMMUNE T CELLS AND ANTIGENS, AND AUTOIMMUNE TREATMENT
审中-公开
MHC II类EPITOPE测定方法，自身免疫细胞和抗原检测及自动治疗
- 专利标题： METHODS OF MHC CLASS II EPITOPE MAPPING, DETECTION OF AUTOIMMUNE T CELLS AND ANTIGENS, AND AUTOIMMUNE TREATMENT
- 专利标题（中）： MHC II类EPITOPE测定方法，自身免疫细胞和抗原检测及自动治疗
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申请号： US12390343申请日： 2009-02-20
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公开(公告)号： US20090226471A1公开(公告)日： 2009-09-10
- 发明人: WILLIAM W. KWOK , GERALD NEPOM , JOHN GEBE , HELENA REIJONEN , ANDREW LIU
- 申请人： WILLIAM W. KWOK , GERALD NEPOM , JOHN GEBE , HELENA REIJONEN , ANDREW LIU
- 申请人地址： US WA SEATTLE
- 专利权人： BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON
- 当前专利权人： BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON
- 当前专利权人地址： US WA SEATTLE
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C12N5/06 ; C12N5/08
摘要：
The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic polypeptide agent for an MHC class II epitope are provided. In other aspects, methods for modulating T cells and for determining or monitoring an MHC class II-restricted immune status of a patient are also provided.
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