公开(公告)号：US20090226471A1

公开(公告)日：2009-09-10

申请号：US12390343

申请日：2009-02-20

申请人： WILLIAM W. KWOK ,  GERALD NEPOM ,  JOHN GEBE ,  HELENA REIJONEN ,  ANDREW LIU

发明人： WILLIAM W. KWOK ,  GERALD NEPOM ,  JOHN GEBE ,  HELENA REIJONEN ,  ANDREW LIU

IPC分类号： A61K39/00 ,  C12N5/06 ,  C12N5/08

CPC分类号： G01N33/56977 ,  A61K39/0008 ,  A61K2039/5156 ,  G01N33/505 ,  G01N33/564 ,  G01N2800/042 ,  G01N2800/24

摘要： The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic polypeptide agent for an MHC class II epitope are provided. In other aspects, methods for modulating T cells and for determining or monitoring an MHC class II-restricted immune status of a patient are also provided.

摘要翻译： 本发明提供使用多聚体MHC II类/肽复合物。 一方面，提供用于鉴定预定多肽抗原的MHC II类限制性免疫表位的方法。 提供了用于鉴定预定多肽抗原的免疫刺激表位的方法。 在相关方面，提供了用于筛选MHC II类表位的治疗性多肽试剂的方法。 在其他方面，还提供了用于调节T细胞和用于确定或监测患者的MHC II类限制性免疫状态的方法。

公开(公告)号：US07094555B2

公开(公告)日：2006-08-22

申请号：US10116846

申请日：2002-04-05

申请人： William W. Kwok ,  Gerald Nepom ,  John Gebe ,  Helena Reijonen ,  Andrew Liu

发明人： William W. Kwok ,  Gerald Nepom ,  John Gebe ,  Helena Reijonen ,  Andrew Liu

IPC分类号： G01N33/53

CPC分类号： G01N33/56977 ,  A61K39/0008 ,  A61K2039/5156 ,  G01N33/505 ,  G01N33/564 ,  G01N2800/042 ,  G01N2800/24

摘要： The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic polypeptide agent for an MHC class II epitope are provided. In other aspects, methods for modulating T cells and for determining or monitoring an MHC class II-restricted immune status of a patient are also provided.

公开(公告)号：US20060240482A1

公开(公告)日：2006-10-26

申请号：US11473862

申请日：2006-06-22

申请人： William Kwok ,  Gerald Nepom ,  John Gebe ,  Helena Reijonen ,  Andrew Liu

发明人： William Kwok ,  Gerald Nepom ,  John Gebe ,  Helena Reijonen ,  Andrew Liu

IPC分类号： A61K35/14 ,  C40B30/06 ,  C40B40/10

CPC分类号： G01N33/56977 ,  A61K39/0008 ,  A61K2039/5156 ,  G01N33/505 ,  G01N33/564 ,  G01N2800/042 ,  G01N2800/24

摘要： The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic polypeptide agent for an MHC class II epitope are provided. In other aspects, methods for modulating T cells and for determining or monitoring an MHC class II-restricted immune status of a patient are also provided.