发明申请
- 专利标题： Myostatin binding agents
- 专利标题（中）： 肌生成抑制素结合剂
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申请号： US12322369申请日： 2009-01-30
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公开(公告)号： US20090227517A1公开(公告)日： 2009-09-10
- 发明人: Hq Han , Hosung Min , Thomas Charles Boone
- 申请人： Hq Han , Hosung Min , Thomas Charles Boone
- 申请人地址： US CA Thousand Oaks
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： US CA Thousand Oaks
- 主分类号： A61K38/08
- IPC分类号： A61K38/08 ; C07K7/06 ; C07K16/22 ; C07H21/00 ; C12N15/63 ; C12N5/10 ; C12P21/02 ; G01N33/68 ; A61P21/00
摘要：
The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such as a polymer or an Fc domain. The binding agents of the present invention produced increased lean muscle mass when administered to animals and decreased fat to muscle ratios. Therapeutic compositions containing the binding agents of the present invention are useful for treating muscle-wasting disorders and metabolic disorders including diabetes and obesity.
公开/授权文献
- US07803923B2 Polynucleotides encoding myostatin binding agents 公开/授权日：2010-09-28
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