发明申请
- 专利标题: NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF
- 专利标题(中): 新戊酸衍生物或其盐
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申请号: US11721007申请日: 2005-12-06
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公开(公告)号: US20090240052A1公开(公告)日: 2009-09-24
- 发明人: Junichi Yokotani , Yoichi Taniguchi , Eiji Hara , Hitoshi Akitsu , Yukie Tada
- 申请人: Junichi Yokotani , Yoichi Taniguchi , Eiji Hara , Hitoshi Akitsu , Yukie Tada
- 申请人地址: JP Shinjuku-ku, Tokyo
- 专利权人: Toyama Chemical Co., Ltd.
- 当前专利权人: Toyama Chemical Co., Ltd.
- 当前专利权人地址: JP Shinjuku-ku, Tokyo
- 优先权: JP2004-353725 20041207
- 国际申请: PCT/JP05/22367 WO 20051206
- 主分类号: C07D413/02
- IPC分类号: C07D413/02 ; C07D277/20 ; C07C229/52 ; C07D213/55 ; C07D209/04 ; C07D241/36
摘要:
An anthranilic acid derivative represented by the general formula (X) [wherein R1 represents hydrogen or a carboxy-protecting group; R2 represents optionally substituted phenyl, a heterocyclic group, etc.; R3 represents optionally substituted phenyl, a monocyclic heterocyclic group, etc.; X1 represents carbonyl, etc.; X2 represents optionally substituted alkylene group, a bond, etc.; X3 represents oxygen, a bond, etc.; and X4 represents a group represented by the general formula -X5-X6- or -X6-X5- (wherein X5 means oxygen, a bond, etc.; and X6 means optionally substituted alkylene, a bond, etc.)] or a salt of the derivative. The derivative or salt has the inhibitory activity of MMP-13 production and is hence useful as a therapeutic agent for articular rheumatism, osteoarthritis, cancer, etc.
公开/授权文献
- US07999132B2 Anthranilic acid derivative or salt thereof 公开/授权日:2011-08-16