发明申请
US20090247476A1 MANNITOL AND/OR PROLINE FOR PREVENTION AND TREATMENT OF AGEING RELATED SYMPTOMS
审中-公开
MANNITOL和/或PROLINE预防和治疗老化相关症状
- 专利标题： MANNITOL AND/OR PROLINE FOR PREVENTION AND TREATMENT OF AGEING RELATED SYMPTOMS
- 专利标题（中）： MANNITOL和/或PROLINE预防和治疗老化相关症状
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申请号： US12300738申请日： 2007-05-14
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公开(公告)号： US20090247476A1公开(公告)日： 2009-10-01
- 发明人: Ingrid van der Pluijm , Gijsbertus van der Horst , Jan Hoeijmakers
- 申请人： Ingrid van der Pluijm , Gijsbertus van der Horst , Jan Hoeijmakers
- 申请人地址： NL Rotterdam
- 专利权人： ERASMUS MC
- 当前专利权人： ERASMUS MC
- 当前专利权人地址： NL Rotterdam
- 优先权： EP06113951.5 20060515
- 国际申请： PCT/NL2007/050205 WO 20070514
- 主分类号： A61K31/7004
- IPC分类号： A61K31/7004 ; A61P39/00
摘要：
The current invention provides new methods and means for the prevention and treatment of ageing-related symptoms and diseases. The invention discloses mannitol 5 and/or proline containing compositions that are particularly useful for the treatment of premature ageing related symptoms in mammalian subjects suffering from genetic defects in DNA damage response and genome maintenance pathways. Humans suffering from Cockayne syndrome (CS), Xeroderma pigmentosum (XP), combined XPCS, trichothiodystrophy (TTD), COFS (cerebro-oculo-facio-skeletal syndrome), 10 XFE disorder (Xpf-Erccl syndrome), Bloom Syndrome (BS), Werner Syndrome (WS), Ataxia telangiectasia (AT), Fanconi Anemia (FA), Hutchinson Guilford Progeria (HGP) may be treated with pharmaceutical compositions comprising mannitol and/or proline according to this invention.
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