发明申请
- 专利标题: Hsp90 FAMILY PROTEIN INHIBITORS
- 专利标题(中): Hsp90家族蛋白抑制剂
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申请号: US12427847申请日: 2009-04-22
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公开(公告)号: US20090247522A1公开(公告)日: 2009-10-01
- 发明人: Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
- 申请人: Shinji Nara , Hiroshi Nakagawa , Yutaka Kanda , Takayuki Nakashima , Shiro Soga , Jiro Kajita , Jun-ichi Saito , Yukimasa Shiotsu , Shiro Akinaga
- 申请人地址: JP Tokyo
- 专利权人: KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人: KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人地址: JP Tokyo
- 优先权: JP2003-185475 20030627
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; A61K31/12 ; A61K31/216 ; A61K31/165 ; A61K31/44 ; A61K31/495 ; A61K31/445 ; A61K31/40 ; A61K31/496 ; A61K31/47 ; A61K31/5375 ; A61P35/00
摘要:
The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.
公开/授权文献
- US07767693B2 Hsp90 family protein inhibitors 公开/授权日:2010-08-03
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