发明申请
- 专利标题: SUBSTITUTED PYRAZOLE DERIVATIVES
- 专利标题(中): 取代的吡唑衍生物
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申请号: US12199008申请日: 2008-08-27
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公开(公告)号: US20090270359A1公开(公告)日: 2009-10-29
- 发明人: Mitsuhiro ITO , Tomohiko SUZAKI , Satoshi YAMAMOTO
- 申请人: Mitsuhiro ITO , Tomohiko SUZAKI , Satoshi YAMAMOTO
- 申请人地址: JP Osaka
- 专利权人: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- 当前专利权人: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- 当前专利权人地址: JP Osaka
- 优先权: JP2007-224910 20070830
- 主分类号: A61K31/415
- IPC分类号: A61K31/415 ; C07D231/12 ; C07D413/08 ; A61K31/5377 ; C07D413/14
摘要:
The present invention provides a novel pyrazole derivative and an androgen receptor antagonist containing the derivative. The present invention provides a compound represented by the formula (I′) wherein R1 is a hydrogen atom, a group via a carbon atom, a group via a nitrogen atom, a group via an oxygen atom, or a group via a sulfur atom; R2 is a phenyl group having cyano (the phenyl group may further have substituent(s) other than cyano); R3 is a hydrogen atom, a group via a carbon atom, a group via a nitrogen atom, a group via an oxygen atom, or a group via a sulfur atom; R4 is a cyclic group optionally having substituent(s); and X is methylene optionally having substituent(s), or CO, or a salt thereof.