发明申请
- 专利标题: Pyrimidinyl pyridone inhibitors of kinases
- 专利标题(中): 嘧啶嘧啶激酶抑制剂
-
申请号: US12387181申请日: 2009-04-29
-
公开(公告)号: US20090270389A1公开(公告)日: 2009-10-29
- 发明人: Frederick Brookfield , Florence Eustache , Michael Patrick Dillon , David Michael Goldstein , Leyi Gong , Xiaochun Han , Joan Heather Hogg , Jaehyeon Park , Deborah Carol Reuter , Eric Brian Sjogren
- 申请人: Frederick Brookfield , Florence Eustache , Michael Patrick Dillon , David Michael Goldstein , Leyi Gong , Xiaochun Han , Joan Heather Hogg , Jaehyeon Park , Deborah Carol Reuter , Eric Brian Sjogren
- 专利权人: Roche Palo Alto LLC
- 当前专利权人: Roche Palo Alto LLC
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; C07D471/04 ; A61K31/519 ; A61P35/00
摘要:
This application discloses novel pyrimidinyl pyridone derivatives according to formula I, wherein A, R1, R2, R3, and m are defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of formula I and methods of treatment comprising administering a therapeutically effective amount of the compound of formula I to a subject in need thereof.
公开/授权文献
- US08268840B2 Pyrimidinyl pyridone inhibitors of kinases 公开/授权日:2012-09-18
信息查询
IPC分类: