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公开(公告)号:US08268840B2
公开(公告)日:2012-09-18
申请号:US12387181
申请日:2009-04-29
申请人: Frederick Brookfield , Florence Eustache , Michael Patrick Dillon , David Michael Goldstein , Leyi Gong , Xiaochun Han , Joan Heather Hogg , Jaehyeon Park , Deborah Carol Reuter , Eric Brian Sjogren
发明人: Frederick Brookfield , Florence Eustache , Michael Patrick Dillon , David Michael Goldstein , Leyi Gong , Xiaochun Han , Joan Heather Hogg , Jaehyeon Park , Deborah Carol Reuter , Eric Brian Sjogren
IPC分类号: A01N43/90 , A61K31/519 , C07D471/00
CPC分类号: C07D471/04
摘要: This application discloses novel pyrimidinyl pyridone derivatives according to formula I, wherein A, R1, R2, R3, and m are defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of formula I and methods of treatment comprising administering a therapeutically effective amount of the compound of formula I to a subject in need thereof.
摘要翻译: 本申请公开了根据式I的新型嘧啶基吡啶酮衍生物,其中A,R1,R2,R3和m如本文所述限定,其抑制JNK。 本文公开的化合物可用于调节JNK的活性并治疗与过量JNK活性相关的疾病。 这些化合物可用于治疗自身免疫性,炎性,代谢和神经疾病以及癌症。 还公开了包含式I化合物和治疗方法的组合物,其包括向有需要的受试者施用治疗有效量的式I化合物。
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公开(公告)号:US20090215750A1
公开(公告)日:2009-08-27
申请号:US12378978
申请日:2009-02-20
申请人: Joe Timothy Bamberg , Mark Bartlett , Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Rama K. Kondru , Remy Lemoine , Yan Lou , Timothy D. Owens , Jaehyeon Park , David Bernard Smith , Michael Soth , Hanbiao Yang , Calvin Wesley Yee
发明人: Joe Timothy Bamberg , Mark Bartlett , Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Rama K. Kondru , Remy Lemoine , Yan Lou , Timothy D. Owens , Jaehyeon Park , David Bernard Smith , Michael Soth , Hanbiao Yang , Calvin Wesley Yee
IPC分类号: A61K31/4985 , C07D487/04 , A61P29/00 , A61K31/541 , A61K31/5377 , A61K31/55
CPC分类号: C07D487/04 , C07D519/00
摘要: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
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公开(公告)号:US20090270389A1
公开(公告)日:2009-10-29
申请号:US12387181
申请日:2009-04-29
申请人: Frederick Brookfield , Florence Eustache , Michael Patrick Dillon , David Michael Goldstein , Leyi Gong , Xiaochun Han , Joan Heather Hogg , Jaehyeon Park , Deborah Carol Reuter , Eric Brian Sjogren
发明人: Frederick Brookfield , Florence Eustache , Michael Patrick Dillon , David Michael Goldstein , Leyi Gong , Xiaochun Han , Joan Heather Hogg , Jaehyeon Park , Deborah Carol Reuter , Eric Brian Sjogren
IPC分类号: A61K31/5377 , C07D471/04 , A61K31/519 , A61P35/00
CPC分类号: C07D471/04
摘要: This application discloses novel pyrimidinyl pyridone derivatives according to formula I, wherein A, R1, R2, R3, and m are defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of formula I and methods of treatment comprising administering a therapeutically effective amount of the compound of formula I to a subject in need thereof.
摘要翻译: 本申请公开了根据式I的新型嘧啶基吡啶酮衍生物,其中A,R1,R2,R3和m如本文所述限定,其抑制JNK。 本文公开的化合物可用于调节JNK的活性并治疗与过量JNK活性相关的疾病。 这些化合物可用于治疗自身免疫性,炎性,代谢和神经疾病以及癌症。 还公开了包含式I化合物和治疗方法的组合物,其包括向有需要的受试者施用治疗有效量的式I化合物。
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公开(公告)号:US07939531B2
公开(公告)日:2011-05-10
申请号:US12378978
申请日:2009-02-20
申请人: Joe Timothy Bamberg , Mark Bartlett , Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Rama K. Kondru , Remy Lemoine , Yan Lou , Timothy D. Owens , Jaehyeon Park , David Bernard Smith , Michael Soth , Hanbiao Yang , Calvin Wesley Yee
发明人: Joe Timothy Bamberg , Mark Bartlett , Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Rama K. Kondru , Remy Lemoine , Yan Lou , Timothy D. Owens , Jaehyeon Park , David Bernard Smith , Michael Soth , Hanbiao Yang , Calvin Wesley Yee
IPC分类号: A61K31/495
CPC分类号: C07D487/04 , C07D519/00
摘要: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译: 本发明涉及式I的新型吡咯并吡嗪衍生物的用途,其中变量Q和R如本文所述定义,其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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