发明申请
- 专利标题: PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
- 专利标题(中): 吡格列酮信号肽的吡啶类抑制剂
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申请号: US12420746申请日: 2009-04-08
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公开(公告)号: US20090281089A1公开(公告)日: 2009-11-12
- 发明人: Janet L. Gunzner , Daniel P. Sutherlin , Mark S. Stanley , Liang Bao , Georgette Castanedo , Rebecca L. LaLonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina
- 申请人: Janet L. Gunzner , Daniel P. Sutherlin , Mark S. Stanley , Liang Bao , Georgette Castanedo , Rebecca L. LaLonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina
- 申请人地址: US CA South San Francisco
- 专利权人: Genentech, Inc.
- 当前专利权人: Genentech, Inc.
- 当前专利权人地址: US CA South San Francisco
- 主分类号: A61K31/444
- IPC分类号: A61K31/444 ; C07D413/14 ; C07D401/14 ; C07D213/56 ; C07D417/12 ; C07D413/12 ; C07D401/12 ; A61P35/00 ; A61K31/5377 ; A61K31/4402 ; A61K31/496 ; A61K31/541 ; A61K31/4439 ; A61K31/506 ; A61K31/551
摘要:
The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.
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