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公开(公告)号：US20090281089A1
公开(公告)日：2009-11-12
申请号：US12420746
申请日：2009-04-08
申请人： Janet L. Gunzner , Daniel P. Sutherlin , Mark S. Stanley , Liang Bao , Georgette Castanedo , Rebecca L. LaLonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina
发明人： Janet L. Gunzner , Daniel P. Sutherlin , Mark S. Stanley , Liang Bao , Georgette Castanedo , Rebecca L. LaLonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina
IPC分类号： A61K31/444 , C07D413/14 , C07D401/14 , C07D213/56 , C07D417/12 , C07D413/12 , C07D401/12 , A61P35/00 , A61K31/5377 , A61K31/4402 , A61K31/496 , A61K31/541 , A61K31/4439 , A61K31/506 , A61K31/551
CPC分类号： C07D213/16 , C07D213/06 , C07D213/56 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07F9/58
摘要： The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.
摘要翻译： 本发明提供了可用作治疗恶性肿瘤的治疗剂的刺猬蛋白信号传导的新型抑制剂，其中化合物具有通式I：其中A，X，Y R1，R2，R3，R4，m和n如本文所述。
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公开(公告)号：US20120094980A1
公开(公告)日：2012-04-19
申请号：US13273945
申请日：2011-10-14
申请人： Janet L. Gunzner , Daniel P. Sutherlin , Mark S. Stanley , Liang Bao , Georgette Castanedo , Rebecca Lalonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina , Michael F.T. Koehler
发明人： Janet L. Gunzner , Daniel P. Sutherlin , Mark S. Stanley , Liang Bao , Georgette Castanedo , Rebecca Lalonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina , Michael F.T. Koehler
IPC分类号： A61K31/551 , A61K31/5377 , C07D401/14 , A61K31/444 , C07D213/56 , A61K31/44 , C07D409/12 , A61K31/4436 , C07D413/12 , A61K31/4439 , C07D403/14 , A61K31/496 , C07D401/12 , A61K31/506 , C07D417/12 , A61K31/541 , A61K31/4545 , C12N5/07 , A61P35/00 , A61P9/00 , C07D413/14
CPC分类号： C07D213/16 , C07D213/06 , C07D213/56 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07F9/58
摘要： The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.
摘要翻译： 本发明提供了可用作治疗恶性肿瘤的治疗剂的刺猬蛋白信号传导的新型抑制剂，其中化合物具有通式I：其中A，X，Y R1，R2，R3，R4，m和n如本文所述。
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公开(公告)号：US09278961B2
公开(公告)日：2016-03-08
申请号：US12960609
申请日：2010-12-06
申请人： Janet L. Gunzner , Daniel Sutherlin , Mark S. Stanley , Liang Bao , Georgette M. Castanedo , Rebecca L. Lalonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina , Michael F. T. Koehler
发明人： Janet L. Gunzner , Daniel Sutherlin , Mark S. Stanley , Liang Bao , Georgette M. Castanedo , Rebecca L. Lalonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina , Michael F. T. Koehler
IPC分类号： C07D213/38 , C07D417/12 , C07D401/14 , A61K31/44 , C07D213/40 , C07D213/56 , C07D213/70 , C07D213/75 , C07D213/81 , C07D213/82 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07F9/58
CPC分类号： C07D213/16 , C07D213/38 , C07D213/40 , C07D213/56 , C07D213/70 , C07D213/75 , C07D213/81 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07F9/58
摘要： The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.
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公开(公告)号：US20110092461A1
公开(公告)日：2011-04-21
申请号：US12960609
申请日：2010-12-06
申请人： Janet L. GUNZNER , Daniel Sutherlin , Mark S. Stanley , Liang Bao , Georgette M. Castanedo , Rebecca L. Lalonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina
发明人： Janet L. GUNZNER , Daniel Sutherlin , Mark S. Stanley , Liang Bao , Georgette M. Castanedo , Rebecca L. Lalonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina
IPC分类号： A61K31/675 , C07D413/12 , C07D401/14 , C07D213/56 , C07D409/12 , C07D401/12 , C07D413/14 , C07D417/12 , A61K31/5377 , A61K31/444 , A61K31/4418 , A61K31/4436 , A61K31/4439 , A61K31/496 , A61K31/506 , A61K31/541 , A61K31/551 , C12N5/071 , A61P35/00
CPC分类号： C07D213/16 , C07D213/38 , C07D213/40 , C07D213/56 , C07D213/70 , C07D213/75 , C07D213/81 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07F9/58
摘要： The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.
摘要翻译： 本发明提供了可用作治疗恶性肿瘤的治疗剂的刺猬蛋白信号传导的新型抑制剂，其中化合物具有通式I：其中A，X，Y R1，R2，R3，R4，m和n如本文所述。
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公开(公告)号：US07888364B2
公开(公告)日：2011-02-15
申请号：US11217663
申请日：2005-09-02
申请人： Janet L. Gunzner , Daniel Sutherlin , Mark S. Stanley , Liang Bao , Georgette M. Castanedo , Rebecca L. Lalonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina
发明人： Janet L. Gunzner , Daniel Sutherlin , Mark S. Stanley , Liang Bao , Georgette M. Castanedo , Rebecca L. Lalonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina
IPC分类号： C07D403/02 , A61K31/4439
CPC分类号： C07D213/16 , C07D213/38 , C07D213/40 , C07D213/56 , C07D213/70 , C07D213/75 , C07D213/81 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07F9/58
摘要： The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.
摘要翻译： 本发明提供了可用作治疗恶性肿瘤的治疗剂的刺猬蛋白信号传导的新型抑制剂，其中化合物具有通式I：其中A，X，Y R1，R2，R3，R4，m和n如本文所述。
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公开(公告)号：US20110112085A1
公开(公告)日：2011-05-12
申请号：US13006217
申请日：2011-01-13
申请人： Georgette M. Castanedo , Janet L. Gunzner , Kimberly Malesky , Simon Mathieu , Alan G. Olivero , Daniel P. Sutherlin , Shumei Wang , Bing-Yan Zhu , Irina Chuckowree , Adrian Folkes , Sally Oxenford , Nan-Chi Wan
发明人： Georgette M. Castanedo , Janet L. Gunzner , Kimberly Malesky , Simon Mathieu , Alan G. Olivero , Daniel P. Sutherlin , Shumei Wang , Bing-Yan Zhu , Irina Chuckowree , Adrian Folkes , Sally Oxenford , Nan-Chi Wan
IPC分类号： A61K31/5377 , A61P35/00 , A61P35/02
CPC分类号： C07D513/04
摘要： Compounds of Formulas Ia and Ib, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译： 式Ia和Ib的化合物，并且包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐可用于抑制脂质激酶（包括PI3K）和用于治疗由脂质激酶介导的癌症等疾病。 公开了将式Ia和Ib化合物用于体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US07846929B2
公开(公告)日：2010-12-07
申请号：US11789427
申请日：2007-04-24
申请人： Adrian Folkes , Stephen Shuttleworth , Sally Oxenford , Tim Hancox , Tracy Bayliss , Georgette Castanedo , Richard Goldsmith , Janet Gunzner , Tim Heffron , Kimberly Malesky , Simon Mathieu , Alan Olivero , Daniel P. Sutherlin , Vickie Tsui , Shumei Wang , Christian Wiesmann , Bing-Yan Zhu , Jennafer Dotson
发明人： Adrian Folkes , Stephen Shuttleworth , Sally Oxenford , Tim Hancox , Tracy Bayliss , Georgette Castanedo , Richard Goldsmith , Janet Gunzner , Tim Heffron , Kimberly Malesky , Simon Mathieu , Alan Olivero , Daniel P. Sutherlin , Vickie Tsui , Shumei Wang , Christian Wiesmann , Bing-Yan Zhu , Jennafer Dotson
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D491/04 , C07D495/04
摘要： Compounds of Formulas Ia and Ib, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译： 式Ia和Ib的化合物，并且包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐可用于抑制脂质激酶（包括PI3K）和用于治疗由脂质激酶介导的癌症等疾病。 公开了将式Ia和Ib化合物用于体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US20110105464A1
公开(公告)日：2011-05-05
申请号：US12916125
申请日：2010-10-29
申请人： Georgette Castanedo , Richard Goldsmith , Janet Gunzner , Tim Heffron , Kimberly Malesky , Simon Mathieu , Alan Olivero , Daniel P. Sutherlin , Vickie Tsui , Shumei Wang , Christian Wiesmann , Bing-Yan Zhu , Jennafer Dotson , Adrian Folkes , Stephen Shuttleworth , Sally Oxenford , Tim Hancox , Tracy Bayliss
发明人： Georgette Castanedo , Richard Goldsmith , Janet Gunzner , Tim Heffron , Kimberly Malesky , Simon Mathieu , Alan Olivero , Daniel P. Sutherlin , Vickie Tsui , Shumei Wang , Christian Wiesmann , Bing-Yan Zhu , Jennafer Dotson , Adrian Folkes , Stephen Shuttleworth , Sally Oxenford , Tim Hancox , Tracy Bayliss
CPC分类号： C07D491/04 , C07D495/04
摘要： Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译： 公开了将式Ia和Ib化合物用于体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US08158626B2
公开(公告)日：2012-04-17
申请号：US13006217
申请日：2011-01-13
申请人： Georgette M. Castanedo , Janet L. Gunzner , Kimberly Malesky , Simon Mathieu , Alan G. Olivero , Daniel P. Sutherlin , Shumei Wang , Bing-Yan Zhu , Irina Chuckowree , Adrian Folkes , Sally Oxenford , Nan Chi Wan
发明人： Georgette M. Castanedo , Janet L. Gunzner , Kimberly Malesky , Simon Mathieu , Alan G. Olivero , Daniel P. Sutherlin , Shumei Wang , Bing-Yan Zhu , Irina Chuckowree , Adrian Folkes , Sally Oxenford , Nan Chi Wan
IPC分类号： A61K31/5377
CPC分类号： C07D513/04
摘要： Compounds of Formulas Ia and Ib, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译： 式Ia和Ib的化合物，并且包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐可用于抑制脂质激酶（包括PI3K）和用于治疗由脂质激酶介导的癌症等疾病。 公开了将式Ia和Ib化合物用于体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US07893059B2
公开(公告)日：2011-02-22
申请号：US12236317
申请日：2008-09-23
申请人： Georgette M. Castanedo , Janet L. Gunzner , Kimberly Malesky , Simon Mathieu , Alan G. Olivero , Daniel P. Sutherlin , Shumei Wang , Bing-Yan Zhu , Irina Chuckowree , Adrian Folkes , Sally Oxenford , Nan Chi Wan
发明人： Georgette M. Castanedo , Janet L. Gunzner , Kimberly Malesky , Simon Mathieu , Alan G. Olivero , Daniel P. Sutherlin , Shumei Wang , Bing-Yan Zhu , Irina Chuckowree , Adrian Folkes , Sally Oxenford , Nan Chi Wan
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D513/04
摘要： Compounds of Formulas Ia and Ib, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译： 式Ia和Ib的化合物，并且包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐可用于抑制脂质激酶（包括PI3K）和用于治疗由脂质激酶介导的癌症等疾病。 公开了将式Ia和Ib化合物用于体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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