发明申请
US20090299036A1 AGENT FOR PREVENTING ARTERIOSCLEROSIS, AGENT FOR SUPPRESSING VASCULAR INTIMAL THICKENING AND AGENT FOR IMPROVING VASCULAR ENDOTHELIAL FUNCTION
审中-公开
用于预防神经功能障碍的药剂，用于抑制血管内增生的药剂和用于改善血管内皮功能的药剂
- 专利标题： AGENT FOR PREVENTING ARTERIOSCLEROSIS, AGENT FOR SUPPRESSING VASCULAR INTIMAL THICKENING AND AGENT FOR IMPROVING VASCULAR ENDOTHELIAL FUNCTION
- 专利标题（中）： 用于预防神经功能障碍的药剂，用于抑制血管内增生的药剂和用于改善血管内皮功能的药剂
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申请号： US12279240申请日： 2007-02-14
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公开(公告)号： US20090299036A1公开(公告)日： 2009-12-03
- 发明人: Tatsuhiko Hirota , Teppei Nakamura , Kohji Ohki , Akihiro Masuyama , Toshiaki Takano , Toshikazu Yoshikawa , Yuji Naito , Hiroshi Ichikawa , Satomi Akagiri
- 申请人： Tatsuhiko Hirota , Teppei Nakamura , Kohji Ohki , Akihiro Masuyama , Toshiaki Takano , Toshikazu Yoshikawa , Yuji Naito , Hiroshi Ichikawa , Satomi Akagiri
- 申请人地址： JP Toyko
- 专利权人： Calpis Co, Ltd
- 当前专利权人： Calpis Co, Ltd
- 当前专利权人地址： JP Toyko
- 优先权： JP2006-035945 20060214; JP2006035946 20060214
- 国际申请： PCT/JP2007/052572 WO 20070214
- 主分类号： C07K5/08
- IPC分类号： C07K5/08 ; C07D207/16 ; C07K14/47
摘要：
There is provided an agent having at least one of an improving effect on vascular endothelial functions and an inhibitory effect on vascular intimal thickening, as well as a prophylactic of arteriosclerosis, which have excellent safety, improve functions associated with the vascular endothelium, have effects of preventing various diseases associated with vascular endothelial functions and of inhibiting vascular intimal thickening, and may be expected to provide prophylactic effect on arteriosclerosis or the like. The agents of the present invention contain, as an active component: (a) Xaa-Pro-Pro, (b) a hydrolysate of animal milk casein containing Xaa-Pro-Pro, or a concentrate thereof, or (c) a fermentation product containing Ile-Pro-Pro and/or Val-Pro-Pro obtained by fermenting a starting material containing milk protein with a bacterial strain of the species Lactobacillus helveticus.
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