发明申请
US20090304657A1 CHIMERIC T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE
审中-公开
CHIMERIC T细胞受体及相关材料及使用方法
- 专利标题： CHIMERIC T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE
- 专利标题（中）： CHIMERIC T细胞受体及相关材料及使用方法
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申请号： US12298927申请日： 2007-05-03
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公开(公告)号： US20090304657A1公开(公告)日： 2009-12-10
- 发明人: Richard A. Morgan , Cyrille J. Cohen , Steven A. Rosenberg
- 申请人： Richard A. Morgan , Cyrille J. Cohen , Steven A. Rosenberg
- 申请人地址： US MD Bethesda
- 专利权人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
- 当前专利权人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
- 当前专利权人地址： US MD Bethesda
- 国际申请： PCT/US07/68113 WO 20070503
- 主分类号： A61K35/12
- IPC分类号： A61K35/12 ; C12N5/08 ; C07K14/705 ; C07H21/04 ; C12N15/63 ; C12N5/00
摘要：
The invention provides a chimeric T cell receptor (TCR) comprising a variable region of a human TCR and a constant region comprising at least an extracellular domain of a constant region of a non-human TCR, as well as functional variants thereof. The invention also provides polypeptides and proteins related to the inventive TCRs, as well as nucleic acids encoding the TCRs, polypeptides, or proteins, recombinant expression vectors, and host cells. Further provided are pharmaceutical compositions related to the inventive TCRs and methods of preventing or treating a disease, e.g., an infectious disease, cancer, in a host, methods of detecting a diseased cell in a host, and methods of improving the biological activity of a TCR.
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