- 专利标题： TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS
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申请号： US12470525申请日： 2009-05-22
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公开(公告)号： US20090304692A1公开(公告)日： 2009-12-10
- 发明人: Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi
- 申请人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi
- 申请人地址： US NJ Madison
- 专利权人： Wyeth
- 当前专利权人： Wyeth
- 当前专利权人地址： US NJ Madison
- 主分类号： A61K31/5375
- IPC分类号： A61K31/5375 ; C07D413/04 ; C07D413/14 ; C07D405/14 ; C07D417/14 ; C07D491/08 ; C07D498/08 ; A61K31/5377 ; A61K31/541 ; A61K31/7068 ; A61K31/675 ; A61K33/24 ; A61K39/395 ; A61P19/00 ; A61P35/00
摘要：
Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
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