发明申请
US20090325905A1 METHOD FOR TREATING DISEASES ASSOCIATED WITH ALTERATIONS IN CELLULAR INTEGRITY USING RHO KINASE INHIBITOR COMPOUNDS
失效
使用RHO激酶抑制剂化合物治疗与细胞质量变化相关的疾病的方法
- 专利标题： METHOD FOR TREATING DISEASES ASSOCIATED WITH ALTERATIONS IN CELLULAR INTEGRITY USING RHO KINASE INHIBITOR COMPOUNDS
- 专利标题（中）： 使用RHO激酶抑制剂化合物治疗与细胞质量变化相关的疾病的方法
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申请号： US12492932申请日： 2009-06-26
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公开(公告)号： US20090325905A1公开(公告)日： 2009-12-31
- 发明人: Ward M. Peterson , John W. Lampe , Tomas Navratil , Scott D. Sorensen , Emilee H. Fulcher
- 申请人： Ward M. Peterson , John W. Lampe , Tomas Navratil , Scott D. Sorensen , Emilee H. Fulcher
- 主分类号： A61K31/675
- IPC分类号： A61K31/675 ; A61K31/55 ; A61K31/5377 ; A61K31/4965 ; A61K31/506 ; A61K31/437 ; A61K31/445 ; A61K31/4439 ; A61K31/4245
摘要：
This invention is directed to methods of preventing or treating diseases or conditions associated with alterations in cellular integrity including alterations in endothelial permeability, excessive cell proliferation or tissue remodeling. Particularly, this invention is directed to methods of treating diabetic nephropathy, malaria, or cancer. The method comprises identifying a subject in need of the treatment, and administering to the subject an effective amount of a novel rho kinase inhibitor compound to treat the disease.
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