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    Method for treating pulmonary diseases using rho kinase inhibitor compounds
    1.
    发明授权
    Method for treating pulmonary diseases using rho kinase inhibitor compounds 失效
    使用rho激酶抑制剂化合物治疗肺部疾病的方法

    公开(公告)号：US08299096B2

    公开(公告)日：2012-10-30

    申请号：US12492494

    申请日：2009-06-26

    申请人： Tomas Navratil ,  Ward M. Peterson ,  John W. Lampe ,  Emilee H. Fulcher ,  Scott D. Sorensen

    发明人： Tomas Navratil ,  Ward M. Peterson ,  John W. Lampe ,  Emilee H. Fulcher ,  Scott D. Sorensen

    IPC分类号： A01N43/40 ,  A61K31/445 ,  C07D211/32 ,  C07D231/56 ,  C07D207/00 ,  C07D295/00

    CPC分类号： A61K31/4545 ,  A61K31/4025 ,  A61K31/416 ,  A61K31/437 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/5377 ,  A61K31/55 ,  C07D401/12

    摘要： This invention is directed to methods of preventing or treating diseases or conditions of the lungs associated with excessive cell proliferation, remodeling, inflammation, vasoconstriction, bronchoconstriction, airway hyperreactivity and edema. Particularly, this invention is directed to methods of treating pulmonary diseases such as asthma; chronic obstructive pulmonary disease; respiratory tract illness caused by respiratory syncytial virus; pulmonary arterial hypertension; acute respiratory distress syndrome and ventilator induced lung injury; cystic fibrosis; bronchiectasis; alpha-1-antitrypsin deficiency; rhinitis; rhinosinusitis; primary ciliary dyskinesia; pneumonia; bronchiolitis caused by agents other than respiratory syncytial virus; and interstitial lung disease including lymphangioleiomyomatosis; idiopathic pulmonary fibrosis; obliterative bronchiolitis or bronchiolitis obliterans organizing pneumonia due to lung transplantation or HSCT; nonspecific interstitial pneumonia; cryptogenic organizing pneumonia; acute interstitial pneumonia; respiratory bronchiolitis-associated interstitial lung disease; or pulmonary sarcoidosis. The method comprises administering to a subject an effective amount of a rho kinase inhibitor compound to treat the disease.

    摘要翻译： 本发明涉及预防或治疗与过度细胞增殖，重塑，炎症，血管收缩，支气管收缩，气道高反应性和水肿相关的肺的疾病或病症的方法。 特别地，本发明涉及治疗肺部疾病如哮喘的方法; 慢性阻塞性肺疾病; 呼吸道合胞病毒引起的呼吸道疾病; 肺动脉高压; 急性呼吸窘迫综合征和呼吸机诱发肺损伤; 囊性纤维化; 支气管扩张 α-1-抗胰蛋白酶缺乏症; 鼻炎; 鼻鼻窦炎 原发性纤毛运动障碍; 肺炎; 由呼吸道合胞病毒以外的药剂引起的细支气管炎; 间质性肺病包括淋巴管平滑肌瘤病; 特发性肺纤维化; 闭塞性细支气管炎或闭塞性细支气管炎由于肺移植或HSCT而组织肺炎; 非特异性间质性肺炎 隐源性机体性肺炎 急性间质性肺炎 呼吸性细支气管炎相关间质性肺病; 或肺结节病。 该方法包括向受试者施用有效量的rho激酶抑制剂化合物以治疗该疾病。

    METHOD FOR TREATING PULMONARY DISEASES USING RHO KINASE INHIBITOR COMPOUNDS
    4.
    发明申请
    METHOD FOR TREATING PULMONARY DISEASES USING RHO KINASE INHIBITOR COMPOUNDS 失效
    使用RHO激酶抑制剂化合物治疗肺部疾病的方法

    公开(公告)号：US20090325958A1

    公开(公告)日：2009-12-31

    申请号：US12492494

    申请日：2009-06-26

    申请人： Tomas Navratil ,  Ward M. Peterson ,  John W. Lampe ,  Emilee H. Fulcher ,  Scott D. Sorensen

    发明人： Tomas Navratil ,  Ward M. Peterson ,  John W. Lampe ,  Emilee H. Fulcher ,  Scott D. Sorensen

    IPC分类号： A61K31/5377 ,  A61K31/454 ,  A61K31/416 ,  A61K31/496 ,  A61K31/4725 ,  A61P11/00

    CPC分类号： A61K31/4545 ,  A61K31/4025 ,  A61K31/416 ,  A61K31/437 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/5377 ,  A61K31/55 ,  C07D401/12

    摘要： This invention is directed to methods of preventing or treating diseases or conditions of the lungs associated with excessive cell proliferation, remodeling, inflammation, vasoconstriction, bronchoconstriction, airway hyperreactivity and edema. Particularly, this invention is directed to methods of treating pulmonary diseases such as asthma; chronic obstructive pulmonary disease; respiratory tract illness caused by respiratory syncytial virus; pulmonary arterial hypertension; acute respiratory distress syndrome and ventilator induced lung injury; cystic fibrosis; bronchiectasis; alpha-1-antitrypsin deficiency; rhinitis; rhinosinusitis; primary ciliary dyskinesia; pneumonia; bronchiolitis caused by agents other than respiratory syncytial virus; and interstitial lung disease including lymphangioleiomyomatosis; idiopathic pulmonary fibrosis; obliterative bronchiolitis or bronchiolitis obliterans organizing pneumonia due to lung transplantation or HSCT; nonspecific interstitial pneumonia; cryptogenic organizing pneumonia; acute interstitial pneumonia; respiratory bronchiolitis-associated interstitial lung disease; or pulmonary sarcoidosis. The method comprises administering to a subject an effective amount of a rho kinase inhibitor compound to treat the disease.

    摘要翻译： 本发明涉及预防或治疗与过度细胞增殖，重塑，炎症，血管收缩，支气管收缩，气道高反应性和水肿相关的肺的疾病或病症的方法。 特别地，本发明涉及治疗肺部疾病如哮喘的方法; 慢性阻塞性肺疾病; 呼吸道合胞病毒引起的呼吸道疾病; 肺动脉高压; 急性呼吸窘迫综合征和呼吸机诱发肺损伤; 囊性纤维化; 支气管扩张 α-1-抗胰蛋白酶缺乏症; 鼻炎; 鼻鼻窦炎 原发性纤毛运动障碍; 肺炎; 由呼吸道合胞病毒以外的药剂引起的细支气管炎; 间质性肺病包括淋巴管平滑肌瘤病; 特发性肺纤维化; 闭塞性细支气管炎或闭塞性细支气管炎由于肺移植或HSCT而组织肺炎; 非特异性间质性肺炎 隐源性机体性肺炎 急性间质性肺炎 呼吸性细支气管炎相关性间质性肺病; 或肺结节病。 该方法包括向受试者施用有效量的rho激酶抑制剂化合物以治疗该疾病。

    METHOD FOR TREATING OPHTHALMIC DISEASES USING RHO KINASE INHIBITOR COMPOUNDS
    8.
    发明申请
    METHOD FOR TREATING OPHTHALMIC DISEASES USING RHO KINASE INHIBITOR COMPOUNDS 审中-公开
    使用RHO激酶抑制剂化合物治疗眼底疾病的方法

    公开(公告)号：US20090325959A1

    公开(公告)日：2009-12-31

    申请号：US12492603

    申请日：2009-06-26

    申请人： Jason L. Vittitow ,  Ward M. Peterson ,  John W. Lampe ,  Tomas Navratil ,  Emilee H. Fulcher

    发明人： Jason L. Vittitow ,  Ward M. Peterson ,  John W. Lampe ,  Tomas Navratil ,  Emilee H. Fulcher

    IPC分类号： A61K31/5377 ,  A61K31/454 ,  A61K31/416 ,  A61K31/496 ,  A61K31/4725 ,  A61P27/02 ,  A61P27/14

    CPC分类号： A61K31/416 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/5377

    摘要： This invention is directed to methods of preventing or treating ocular diseases with inflammation, excessive cell proliferation, remodeling, neurite retraction, corneal neurodegeneration, excessive vaso-permeability and edema. Particularly, this invention relates to methods treating ocular diseases such as allergic conjunctivitis, corneal hyposensitivity, neurotrophic keratopathy, dry eye disease, proliferative vitreal retinopathy, macular edema, macular degeneration, and blepharitis, using novel Rho kinase inhibitor compounds. The method comprises identifying a subject in need of the treatment, and administering to the subject an effective amount of a novel Rho kinase inhibitor compound to treat the disease.

    摘要翻译： 本发明涉及预防或治疗具有炎症，过度细胞增殖，重塑，神经突回缩，角膜神经变性，过度血管通透性和水肿的眼部疾病的方法。 特别地，本发明涉及使用新型Rho激酶抑制剂化合物治疗眼部疾病如过敏性结膜炎，角膜过敏症，神经营养性角膜病，干眼病，增殖性玻璃体视网膜病变，黄斑水肿，黄斑变性和睑炎的治疗方法。 该方法包括鉴定需要治疗的受试者，并向受试者施用有效量的新型Rho激酶抑制剂化合物以治疗该疾病。

    METHOD OF TREATING PULMONARY EDEMA OR PULMONARY INFLAMMATION
    10.
    发明申请
    METHOD OF TREATING PULMONARY EDEMA OR PULMONARY INFLAMMATION 审中-公开
    治疗肺动脉高压或肺动脉炎的方法

    公开(公告)号：US20090098064A1

    公开(公告)日：2009-04-16

    申请号：US12293260

    申请日：2007-03-16

    申请人： Tomas Navratil ,  Kurt E. Brubaker ,  Jose L. Boyer ,  Ward M. Peterson ,  Ramesh Krishnamoorthy

    发明人： Tomas Navratil ,  Kurt E. Brubaker ,  Jose L. Boyer ,  Ward M. Peterson ,  Ramesh Krishnamoorthy

    IPC分类号： A61K9/12 ,  A61K38/47

    CPC分类号： A61K38/46 ,  C12Y306/01005 ,  C12Y306/01006

    摘要： The invention provides a method for preventing or treating pulmonary edema and/or pulmonary inflammation in a subject by the administration of at least one nucleotidase. The subject is preferably a human subject. The nucleotidase is preferably of a mammalian origin, such as a human origin. The NTPDase and NPP families of nucleotidases are particularly useful for the present invention. The method reduces the bioavailability of in situ signaling extracellular nucleotides, thereby disturbing the pathological pathways in ventilator-induced lung injury (VILI) and respiratory syncytial virus infection (RSV) and other disorders such as chronic obstructive pulmonary disorder. Local administration such as inhalation is a preferred route of administration.

    摘要翻译： 本发明提供了通过施用至少一种核苷酸酶来预防或治疗受试者的肺水肿和/或肺部炎症的方法。 受试者优选为人受试者。 核苷酸酶优选为哺乳动物来源，例如人源。 核苷酸酶的NTPDase和NPP家族对本发明特别有用。 该方法降低了原位信号转导细胞外核苷酸的生物利用度，从而扰乱呼吸机诱发的肺损伤（VILI）和呼吸道合胞病毒感染（RSV）以及其他疾病如慢性阻塞性肺病的病理学途径。 局部给药如吸入是优选的给药途径。