发明申请
US20100004738A1 DRUG DELIVERY COATING FOR USE WITH A MEDICAL DEVICE AND METHODS OF TREATING VASCULAR INJURY
审中-公开
用于医疗设备的药物输送涂料和治疗血管损伤的方法
- 专利标题： DRUG DELIVERY COATING FOR USE WITH A MEDICAL DEVICE AND METHODS OF TREATING VASCULAR INJURY
- 专利标题（中）： 用于医疗设备的药物输送涂料和治疗血管损伤的方法
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申请号： US11919315申请日： 2006-04-28
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公开(公告)号： US20100004738A1公开(公告)日： 2010-01-07
- 发明人: Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Theodore Karwoski , Trevor Carlton
- 申请人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Theodore Karwoski , Trevor Carlton
- 申请人地址： US NH Hudson
- 专利权人： ATRIUM MEDICAL CORPORATION
- 当前专利权人： ATRIUM MEDICAL CORPORATION
- 当前专利权人地址： US NH Hudson
- 国际申请： PCT/US2006/016502 WO 20060428
- 主分类号： A61F2/82
- IPC分类号： A61F2/82 ; A61F2/00 ; A61K31/439 ; A61M25/00 ; A61B17/03
摘要：
The present inventions provide various embodiments of methods for one or more of treating vascular injury, neointima proliferation and/or local inflammation in a mammal by locally administering therapeutic compound comprising a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the therapeutic compound comprises a bio-absorbable carrier component carrier component at least partially formed of a cellular uptake inhibitor and a cellular uptake enhancer, a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the present invention provides for controlled delivery, which is at least partially characterized by total and relative amounts of a cellular uptake inhibitor and cellular uptake enhancer in a bio-absorbable carrier component.
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