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    DRUG DELIVERY COATING FOR USE WITH A MEDICAL DEVICE AND METHODS OF TREATING VASCULAR INJURY
    1.
    发明申请
    DRUG DELIVERY COATING FOR USE WITH A MEDICAL DEVICE AND METHODS OF TREATING VASCULAR INJURY 审中-公开
    用于医疗设备的药物输送涂料和治疗血管损伤的方法

    公开(公告)号：US20100004738A1

    公开(公告)日：2010-01-07

    申请号：US11919315

    申请日：2006-04-28

    申请人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Theodore Karwoski ,  Trevor Carlton

    发明人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Theodore Karwoski ,  Trevor Carlton

    IPC分类号： A61F2/82 ,  A61F2/00 ,  A61K31/439 ,  A61M25/00 ,  A61B17/03

    CPC分类号： A61K31/436 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/434 ,  A61L2300/45

    摘要： The present inventions provide various embodiments of methods for one or more of treating vascular injury, neointima proliferation and/or local inflammation in a mammal by locally administering therapeutic compound comprising a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the therapeutic compound comprises a bio-absorbable carrier component carrier component at least partially formed of a cellular uptake inhibitor and a cellular uptake enhancer, a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the present invention provides for controlled delivery, which is at least partially characterized by total and relative amounts of a cellular uptake inhibitor and cellular uptake enhancer in a bio-absorbable carrier component.

    摘要翻译： 本发明提供了通过局部施用包含mTOR靶向化合物和钙调磷酸酶抑制剂的治疗化合物来治疗哺乳动物血管损伤，新内膜增生和/或局部炎症中的一种或多种的方法的各种实施方案。 在各个方面，治疗化合物包括至少部分由细胞摄取抑制剂和细胞吸收增强剂，mTOR靶向化合物和钙调磷酸酶抑制剂形成的生物可吸收载体组分载体组分。 在各个方面，本发明提供受控递送，其至少部分地表征为生物可吸收载体组分中的细胞摄取抑制剂和细胞摄取增强剂的总量和相对量。

    Application of a therapeutic substance to a tissue location using an expandable medical device
    3.
    发明授权
    Application of a therapeutic substance to a tissue location using an expandable medical device 有权
    使用可扩张医疗装置将治疗物质施用于组织位置

    公开(公告)号：US07572245B2

    公开(公告)日：2009-08-11

    申请号：US10942764

    申请日：2004-09-15

    申请人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    发明人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    IPC分类号： A61M31/00

    CPC分类号： A61L29/16 ,  A61L31/16 ,  A61L2300/606

    摘要： A non-polymeric or biological coating applied to radially expandable interventional medical devices provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device. Thus, atraumatic local tissue transference delivery is achieved for uniform therapeutic agent distribution and controlled bio-absorption into the tissue after placement within a patient's body with a non-inflammatory coating.

    摘要翻译： 施加到可径向扩张的介入医疗装置的非聚合或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。 因此，在用非炎性涂层放置在患者体内之后，实现了不均匀的局部组织转移递送，用于均匀的治疗剂分布和对组织的受控生物吸收。

    Application of a therapeutic substance to a tissue location using an expandable medical device
    6.
    发明授权
    Application of a therapeutic substance to a tissue location using an expandable medical device 有权
    使用可扩张医疗装置将治疗物质施用于组织位置

    公开(公告)号：US07947015B2

    公开(公告)日：2011-05-24

    申请号：US11804478

    申请日：2007-05-18

    申请人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    发明人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    IPC分类号： A61M37/00

    CPC分类号： A61M25/1027 ,  A61L29/085 ,  A61L29/146 ,  A61L29/16 ,  A61L2300/22 ,  A61L2300/606 ,  A61M2025/1075 ,  A61M2025/1088 ,  C08L27/18

    摘要： A non-polymeric or biological coating applied to radially expandable medical delivery device provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The delivery device is expanded using the pressure of an inflation fluid. After expanding the delivery device to a pre-determined size and shape, the inflation fluid weeps through the porous surface of the delivery device. The coating releases the delivery device and floats on the inflation fluid until bonding to the tissue due to its affinity for the tissue. Once the coating bonds or affixes to the tissue, through an absorption mechanism by the tissue cells of the coating material, the coating and any therapeutics contained therein are delivered to the tissue. The fluid can contain a therapeutic agent, or can be otherwise biocompatible and/or inert.

    摘要翻译： 应用于可径向扩张的医疗输送装置的非聚合物或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。 输送装置使用充气流体的压力膨胀。 在将输送装置膨胀至预定尺寸和形状之后，充气流体通过输送装置的多孔表面而流失。 涂层释放输送装置并漂浮在充气流体上，直到由于其对组织的亲和力而结合到组织。 一旦涂层通过涂层材料的组织细胞通过吸收机制结合或固定到组织，涂层和其中包含的任何治疗剂被递送到组织。 流体可以含有治疗剂，或者可以以其他方式生物相容和/或惰性。

    Application of a therapeutic substance to a tissue location using a porous medical device
    9.
    发明申请
    Application of a therapeutic substance to a tissue location using a porous medical device 审中-公开
    使用多孔医疗装置将治疗物质施用于组织位置

    公开(公告)号：US20050113687A1

    公开(公告)日：2005-05-26

    申请号：US10943075

    申请日：2004-09-15

    申请人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    发明人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    IPC分类号： A61B5/05 ,  A61F2/82 ,  A61M20060101

    CPC分类号： A61M25/10 ,  A61F2/82 ,  A61F2/958 ,  A61F2250/0067 ,  A61M25/1027 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1088

    摘要： A non-polymeric or biological coating applied to porous radially expandable interventional medical devices provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device. Thus, atraumatic local tissue transference delivery is achieved for uniform therapeutic agent distribution and controlled bio-absorption into the tissue after placement within a patient's body with a non-inflammatory coating.

    摘要翻译： 应用于多孔径向可扩张介入医疗装置的非聚合物或生物涂层提供了涂层和与其混合的任何治疗剂的均匀药物分布和渗透到体内的目标治疗区域。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。 因此，在用非炎性涂层放置在患者体内之后，实现了不均匀的局部组织转移递送，用于均匀的治疗剂分布和对组织的受控生物吸收。

    Application of a therapeutic substance to a tissue location using an expandable medical device
    10.
    发明申请
    Application of a therapeutic substance to a tissue location using an expandable medical device 有权
    使用可扩张医疗装置将治疗物质施用于组织位置

    公开(公告)号：US20050106206A1

    公开(公告)日：2005-05-19

    申请号：US10942764

    申请日：2004-09-15

    申请人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    发明人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    IPC分类号： A61K9/22 ,  A61K31/225 ,  A61L29/16 ,  A61L31/16 ,  A61M20060101 ,  A61M25/16

    CPC分类号： A61L29/16 ,  A61L31/16 ,  A61L2300/606

    摘要： A non-polymeric or biological coating applied to radially expandable interventional medical devices provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device. Thus, atraumatic local tissue transference delivery is achieved for uniform therapeutic agent distribution and controlled bio-absorption into the tissue after placement within a patient's body with a non-inflammatory coating.

    摘要翻译： 施加到可径向扩张的介入医疗装置的非聚合或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。 因此，在用非炎性涂层放置在患者体内之后，实现了不均匀的局部组织转移递送，用于均匀的治疗剂分布和对组织的受控生物吸收。