发明申请
- 专利标题: PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR HYPERLIPIDEMIA
- 专利标题(中): 高效药物和/或治疗药物
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申请号: US12593356申请日: 2008-03-28
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公开(公告)号: US20100069433A1公开(公告)日: 2010-03-18
- 发明人: Toshiaki Takizawa , Noriyuki Inoue , Katsutoshi Miyosawa
- 申请人: Toshiaki Takizawa , Noriyuki Inoue , Katsutoshi Miyosawa
- 申请人地址: JP Nagoya-shi, Aichi
- 专利权人: KOWA COMPANY, LTD.
- 当前专利权人: KOWA COMPANY, LTD.
- 当前专利权人地址: JP Nagoya-shi, Aichi
- 优先权: JP2007-087081 20070329
- 国际申请: PCT/JP2008/000788 WO 20080328
- 主分类号: A61K31/47
- IPC分类号: A61K31/47 ; A61K31/42
摘要:
The present invention provides a therapeutic agent for hyperlipidemia having an excellent effect of lowering the cholesterol and triglyceride level in blood plasma.The present invention relates to a prophylactic and/or therapeutic agent for hyperlipidemia, a prophylactic and/or therapeutic agent for obesity or diabetes mellitus, and a prophylactic and/or therapeutic agent for metabolic syndrome, each agent including a compound represented by the following formula (1): , wherein: R1 and R2, which may be identical or different, each represent a hydrogen atom, a methyl group or an ethyl group; R3a, R3b, R4a and R4b, which may be identical or different, each represent a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C1-4 alkyl group, a trifluoromethyl group, a C1-4 alkoxy group, a C1-4 alkylcarbonyloxy group, a di-C1-4 alkylamino group, a C1-4 alkylsulfonyloxy group, a C1-4 alkylsulfonyl group, a C1-4 alkylsulfinyl group, or a C1-4 alkylthio group, or R3a and R3b, or R4a and R4b are joined to represent an alkylenedioxy group; X represents an oxygen atom, a sulfur atom or N—R5 (wherein R5 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylsulfonyl group, or a C1-4 alkyloxycarbonyl group); Y represents an oxygen atom, a S(O)l group (l represents a number from 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, an aminosulfonyl group, or an NH group; Z represents CH or N; n represents a number from 1 to 6; and m represents a number from 2 to 6, or a salt thereof, and a statin, particularly pitavastatin, in combination.
公开/授权文献
- US08426455B2 Prophylactic and/or therapeutic agent for hyperlipidemia 公开/授权日:2013-04-23
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