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    Prophylactic and/or therapeutic agent for hyperlipidemia
    1.
    发明授权
    Prophylactic and/or therapeutic agent for hyperlipidemia 有权
    预防和/或治疗高脂血症的药物

    公开(公告)号：US08426455B2

    公开(公告)日：2013-04-23

    申请号：US12593356

    申请日：2008-03-28

    申请人： Toshiaki Takizawa ,  Noriyuki Inoue ,  Katsutoshi Miyosawa

    发明人： Toshiaki Takizawa ,  Noriyuki Inoue ,  Katsutoshi Miyosawa

    IPC分类号： A61K31/42

    CPC分类号： C07D263/58 ,  A61K31/423 ,  A61K31/47

    摘要： The present invention provides a therapeutic agent for hyperlipidemia having an excellent effect of lowering the cholesterol and triglyceride level in blood plasma.The present invention relates to a prophylactic and/or therapeutic agent for hyperlipidemia, a prophylactic and/or therapeutic agent for obesity or diabetes mellitus, and a prophylactic and/or therapeutic agent for metabolic syndrome, each agent including a compound represented by the formula (1), or a salt thereof, and a statin, particularly pitavastatin, in combination.

    摘要翻译： 本发明提供了具有降低血浆中胆固醇和甘油三酯水平的优异效果的高脂血症治疗剂。 本发明涉及高脂血症的预防和/或治疗剂，肥胖或糖尿病的预防和/或治疗剂，以及代谢综合征的预防和/或治疗剂，每种试剂包括由式（ 1）或其盐，他汀类，特别是匹伐他汀组合。

    PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR HYPERLIPIDEMIA
    2.
    发明申请
    PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR HYPERLIPIDEMIA 有权
    高效药物和/或治疗药物

    公开(公告)号：US20100069433A1

    公开(公告)日：2010-03-18

    申请号：US12593356

    申请日：2008-03-28

    申请人： Toshiaki Takizawa ,  Noriyuki Inoue ,  Katsutoshi Miyosawa

    发明人： Toshiaki Takizawa ,  Noriyuki Inoue ,  Katsutoshi Miyosawa

    IPC分类号： A61K31/47 ,  A61K31/42

    CPC分类号： C07D263/58 ,  A61K31/423 ,  A61K31/47

    摘要： The present invention provides a therapeutic agent for hyperlipidemia having an excellent effect of lowering the cholesterol and triglyceride level in blood plasma.The present invention relates to a prophylactic and/or therapeutic agent for hyperlipidemia, a prophylactic and/or therapeutic agent for obesity or diabetes mellitus, and a prophylactic and/or therapeutic agent for metabolic syndrome, each agent including a compound represented by the following formula (1): , wherein: R1 and R2, which may be identical or different, each represent a hydrogen atom, a methyl group or an ethyl group; R3a, R3b, R4a and R4b, which may be identical or different, each represent a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C1-4 alkyl group, a trifluoromethyl group, a C1-4 alkoxy group, a C1-4 alkylcarbonyloxy group, a di-C1-4 alkylamino group, a C1-4 alkylsulfonyloxy group, a C1-4 alkylsulfonyl group, a C1-4 alkylsulfinyl group, or a C1-4 alkylthio group, or R3a and R3b, or R4a and R4b are joined to represent an alkylenedioxy group; X represents an oxygen atom, a sulfur atom or N—R5 (wherein R5 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylsulfonyl group, or a C1-4 alkyloxycarbonyl group); Y represents an oxygen atom, a S(O)l group (l represents a number from 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, an aminosulfonyl group, or an NH group; Z represents CH or N; n represents a number from 1 to 6; and m represents a number from 2 to 6, or a salt thereof, and a statin, particularly pitavastatin, in combination.

    摘要翻译： 本发明提供了具有降低血浆中胆固醇和甘油三酯水平的优异效果的高脂血症治疗剂。 本发明涉及高脂血症的预防和/或治疗剂，肥胖症或糖尿病的预防和/或治疗剂，以及代谢综合征的预防和/或治疗剂，每种试剂包括由下式表示的化合物 （1）表示：其中：R 1和R 2可以相同或不同，各自表示氢原子，甲基或乙基; R3a，R3b，R4a和R4b可以相同或不同，分别表示氢原子，卤素原子，硝基，羟基，C1-4烷基，三氟甲基，C1-4烷氧基 ，C 1-4烷基羰基氧基，二-C 1-4烷基氨基，C 1-4烷基磺酰氧基，C 1-4烷基磺酰基，C 1-4烷基亚磺酰基或C 1-4烷硫基，或R 3a和R 3b ，或R4a和R4b连接以代表亚烷基二氧基; X表示氧原子，硫原子或N-R5（其中，R5表示氢原子，C1-4烷基，C1-4烷基磺酰基或C1-4烷氧基羰基）。 Y表示氧原子，S（O）1基（l表示0〜2的数），羰基，羰基氨基，氨基羰基，磺酰基氨基，氨基磺酰基或NH基。 Z表示CH或N; n表示1〜6的数; m代表2至6的数，或其盐，他汀类，特别是匹伐他汀组合。

    Pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same
    10.
    发明授权
    Pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same 失效
    具有苄基（吡啶基甲基）胺结构的嘧啶化合物及其组合物

    公开(公告)号：US07750019B2

    公开(公告)日：2010-07-06

    申请号：US11835127

    申请日：2007-08-07

    申请人： Tadaaki Ohgiya ,  Toru Miura ,  Ayumu Okuda ,  Toshiharu Arai ,  Koichi Yamazaki ,  Taro Aoki ,  Katsutoshi Miyosawa ,  Haruki Shibata ,  Kimiyuki Shibuya

    发明人： Tadaaki Ohgiya ,  Toru Miura ,  Ayumu Okuda ,  Toshiharu Arai ,  Koichi Yamazaki ,  Taro Aoki ,  Katsutoshi Miyosawa ,  Haruki Shibata ,  Kimiyuki Shibuya

    IPC分类号： C07D239/42 ,  A61K31/505

    CPC分类号： C07D401/12

    摘要： A compound represented by the following general formula (I) or a salt thereof, or a solvate thereof: (wherein R1, R2, R3, R4 and R5 are the same or different, and represent hydrogen atom, a halogen atom, a lower alkyl group etc., R6, R7 and R8 are the same or different, and represent hydrogen atom, a halogen atom, a lower alkyl group etc., R9 and R10 are the same or different, and represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group etc., and R11 represents hydrogen atom, a halogen atom, a lower alkoxy group, a (lower alkyl)thio(lower alkoxy) group, a (lower alkyl)sulfinyl(lower alkoxy) group, a (lower alkyl)sulfonyl(lower alkoxy) group etc.), which has potent inhibitory activity on CETP.

    摘要翻译： 由下列通式（I）表示的化合物或其盐或其溶剂化物：（其中R1，R2，R3，R4和R5相同或不同，表示氢原子，卤素原子，低级烷基 基团等，R6，R7和R8相同或不同，表示氢原子，卤素原子，低级烷基等，R9和R10相同或不同，表示氢原子，低级烷基， （低级环烷基）（低级烷基）等，R11表示氢原子，卤素原子，低级烷氧基，（低级烷基）硫代（低级烷氧基），（低级烷基）亚磺酰基（低级烷氧基） 基团，（低级烷基）磺酰基（低级烷氧基）等），其对CETP具有有效的抑制活性。